Related Experiment Video

Updated: Aug 20, 2025

Protocol for the Solid-phase Synthesis of Oligomers of RNA Containing a 2'-O-thiophenylmethyl Modification and Characterization via Circular Dichroism
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Protocol for the Solid-phase Synthesis of Oligomers of RNA Containing a 2'-O-thiophenylmethyl Modification and Characterization via Circular Dichroism

Published on: July 28, 2017

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N2 modified dinucleotide cap analogs as a potent tool for mRNA engineering

Renata Grzela1, Karolina Piecyk2, Anna Stankiewicz-Drogon1

  • 1Division of Biophysics, Institute of Experimental Physics, University of Warsaw, 02-093 Warsaw, Poland.

RNA (New York, N.Y.)
|November 23, 2022
PubMed
Summary

Novel N2-modified guanine cap analogs enhance mRNA vaccine technology. These modified dinucleotides ensure correct incorporation and boost mRNA translation efficiency in vitro and in human cells.

Keywords:
cap analogscap-dependent translationmRNAmRNA technologymRNA therapeutics

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