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Strategies to enhance CAR-T persistence

Yue Liu1, Lingna An1, Ruihao Huang1

  • 1Medical Center of Hematology, Xinqiao Hospital, State Key Laboratory of Trauma, Burn and Combined Injury, Army Medical University, 400037, Chongqing, China.

Biomarker Research
|November 24, 2022
PubMed
Summary

Chimeric antigen receptor T-cell (CAR-T) therapy shows promise for B-cell malignancies but struggles with CAR-T cell persistence. Strategies during in vitro culture can enhance CAR-T cell longevity and improve patient outcomes.

Keywords:
CAR-T optimizationDifferentiationImmunotherapyMetabolismPersistence

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