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Updated: Aug 20, 2025

Implantation of Total Artificial Heart in Congenital Heart Disease
07:27

Implantation of Total Artificial Heart in Congenital Heart Disease

Published on: July 18, 2014

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Outcomes of malignancy in adults with congenital heart disease: a single center experience

Prashanth Venkatesh1, Kimberly L Yan2, Katia Bravo-Jaimes3

  • 1Guerin Congenital Heart Program, Department of Cardiology, Cedars-Sinai Medical Center, 127 S. San Vicente Blvd, Suite A3600, Los Angeles, CA, 90048, USA. prv1405@gmail.com.

Cardio-Oncology (London, England)
|November 24, 2022
PubMed

Insights

Adult congenital heart disease (ACHD) patients with cancer face significant mortality, primarily from cancer itself. Cardiovascular events are common, but cardiotoxicity rarely forces cancer treatment changes.

Area of Science:

  • Cardiology
  • Oncology
  • Adult Congenital Heart Disease

Background:

  • Malignancy is a leading cause of death in adult congenital heart disease (ACHD) patients.
  • Limited data exists on cardiovascular and cancer outcomes in this population.

Purpose of the Study:

  • To investigate cardiovascular and cancer-related outcomes in patients with ACHD and malignancy.
  • To identify predictors of mortality and major adverse cardiovascular and cerebrovascular events (MACCE).

Main Methods:

  • Retrospective single-center cohort study of ACHD patients with cancer.
  • Primary outcome: all-cause mortality.
  • Secondary outcomes: MACCE, cardiotoxicity, and cancer therapy modifications.

Main Results:

  • 24% of 68 ACHD patients with cancer died over 5 years, mostly from cancer (69%).
  • Predictors of mortality included baseline arrhythmia, diuretic therapy, and advanced cancer stage.
  • 59% experienced MACCE, independently predicted by diuretic use; 14% had cardiotoxicity.

Conclusions:

  • ACHD patients with cancer experience substantial cancer-related mortality.
  • High rates of MACCE were observed, but cardiotoxicity rarely necessitated cancer therapy changes.
Abstract

Keywords:
Adult congenital heart diseaseCardio-oncologyCardiotoxicityIncidenceLong-term outcomes

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