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Genetically high angiotensin-converting enzyme concentrations causally increase asthma risk: A meta-analysis using
1Department of Pediatrics, China-Japan Friendship Hospital, Beijing, China.
Frontiers in Medicine
|November 24, 2022
Summary
This meta-analysis found that the angiotensin-converting enzyme (ACE) gene I/D polymorphism is linked to increased asthma risk. Higher circulating ACE levels are causally associated with asthma development.
Area of Science:
- Genetics and Respiratory Medicine
- Molecular Biology and Epidemiology
Background:
- The angiotensin-converting enzyme (ACE) gene I/D polymorphism is a potential risk factor for asthma.
- Investigating the association between ACE gene variants and asthma susceptibility is crucial for understanding disease mechanisms.
Approach:
- A comprehensive meta-analysis was conducted, synthesizing data from 19 studies involving 2,888 asthma patients and 9,549 controls.
- Statistical methods included odds ratios (ORs) and standardized mean differences (SMDs) with 95% confidence intervals (CIs).
- Mendelian randomization analyses were employed to assess causality.
Key Points:
- The ACE gene I/D polymorphism showed a significant association with asthma risk across allelic, homozygous genotypic, and recessive models.
- Individuals with DD or ID genotypes exhibited significantly higher circulating ACE concentrations compared to II genotype carriers.
- Heterogeneity in findings was potentially explained by factors such as race, study matching, asthma diagnosis, sample size, and age.
Conclusions:
- This meta-analysis provides robust evidence supporting a causal link between elevated circulating ACE concentrations and asthma development.
- The findings highlight the role of the ACE pathway in asthma pathogenesis and suggest potential therapeutic targets.
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