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RNAME: A comprehensive database of RNA modification enzymes
Fulei Nie1,2, Qiang Tang3,4, Ying Liu2
1School of Public Health, North China University of Science and Technology, Tangshan 063210, China.
Computational and Structural Biotechnology Journal
|November 24, 2022
Summary
A new database, RNAME, catalogs over 21,000 RNA modification enzymes from 456 species. This resource aids researchers by centralizing information on enzymes that install, recognize, and remove RNA modifications.
Area of Science:
- Molecular Biology
- Bioinformatics
- Genomics
Background:
- RNA modifications are dynamically regulated by enzymes.
- A limited number of RNA modification enzymes have been experimentally validated.
- A centralized resource for RNA modification enzymes is needed.
Purpose of the Study:
- To develop a comprehensive database for RNA modification enzymes.
- To provide a valuable resource for researchers studying RNA modifications.
Main Methods:
- Manual curation of RNA modification enzyme data.
- Integration of enzyme information including 3D structures, domains, subcellular locations, and functions.
- Database development and population.
Main Results:
- The RNAME database (https://chenweilab.cn/rname/) was developed.
- RNAME contains over 21,000 manually curated RNA modification enzymes.
- Data spans 456 species and covers 7 common RNA modifications.
Conclusions:
- RNAME serves as a comprehensive resource for RNA modification enzymes.
- The database integrates diverse information, including structural and functional data.
- RNAME is expected to significantly advance research in RNA modifications.
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