Related Experiment Video

Updated: Aug 20, 2025

Author Spotlight: Enhancing the Offspring Health in Rats with Maternal Exercise During Pregnancy
05:17

Author Spotlight: Enhancing the Offspring Health in Rats with Maternal Exercise During Pregnancy

Published on: April 5, 2024

878

Impact of offspring endothelial function from de novo hypertensive disorders during pregnancy: An evidence-based

Aslah Nabilah Abdull Sukor1, Sheril June Ankasha1, Azizah Ugusman1

  • 1Department of Physiology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.

Frontiers in Surgery
|November 24, 2022
PubMed

Insights

Hypertensive disorders of pregnancy (HDP) can impair offspring cardiovascular health. This review found that HDP negatively impacts endothelial function in children, increasing long-term cardiovascular disease risk.

Area of Science:

  • Obstetrics and Gynecology
  • Cardiovascular Medicine
  • Pediatrics

Background:

  • Hypertensive disorders of pregnancy (HDP), including gestational hypertension and preeclampsia, pose risks to maternal and offspring health.
  • HDP is linked to maternal complications and may increase offspring's long-term cardiovascular disease (CVD) risk.
  • Endothelial dysfunction is a key factor in CVD development.

Purpose of the Study:

  • To systematically review and identify studies examining the impact of de novo HDP on offspring endothelial function.
  • To synthesize current evidence on the relationship between HDP exposure in utero and vascular health in offspring.

Main Methods:

  • A comprehensive literature search was performed across PubMed, Scopus, and Medline databases.
  • Searches covered articles published from 1976 to 2022, supplemented by additional sources.
  • Data from 13 selected studies were extracted and analyzed.

Main Results:

  • All reviewed studies indicated impaired endothelial function in offspring exposed to de novo HDP.
  • Key findings suggest links to impaired vasodilation, early atherosclerosis, inflammation, and epigenetic dysregulation.
  • Offspring of pregnancies with HDP exhibit compromised vascular health.

Conclusions:

  • De novo HDP significantly affects offspring endothelial function.
  • This dysfunction may contribute to an increased risk of developing cardiovascular diseases later in life.
  • Further research into the mechanisms and long-term consequences is warranted.

Keywords:
cardiovascular diseaseendothelial functionhypertensive disorders of pregnancyoffspringpreeclampsia

More Related Videos

A Rat Model of Mild Intrauterine Hypoperfusion with Microcoil Stenosis06:19

A Rat Model of Mild Intrauterine Hypoperfusion with Microcoil Stenosis

Published on: January 7, 2018

10.5K
Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles05:31

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles

Published on: January 26, 2024

899

Related Concept Videos

Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
43
Teratogenicity01:07

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
2.6K
Hormonal Regulation01:33

Hormonal Regulation

The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.
33.6K
Hypertension and Regulation of Blood Pressure01:18

Hypertension and Regulation of Blood Pressure

Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
2.2K
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
30
Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists01:18

Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists

Endothelins (ETs) are potent vasoactive peptides critical in the human body's various physiological and pathological processes. One of the most promising therapeutic strategies for treating pulmonary arterial hypertension (PAH) involves counteracting the effects of these endothelins using a class of drugs known as endothelin receptor antagonists.
ETs are synthesized through a complex sequence of enzymatic steps, primarily involving an enzyme referred to as endothelin-converting enzyme...
215