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Published on: May 13, 2022
An 'AND'-based ratiometric fluorescence probe for the sequential detection of biothiols and hypochlorous acid
Hong Zhang1, Ling-Ling Li1, Lei Shi1
1Key Laboratory of Green Chemistry and Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu, 610064, P. R. China. kli@scu.edu.cn.
Abstract:
An 'AND'-based ratiometric fluorescence probe for the sequential detection of biothiols and hypochlorous acid was developed. FRET was observed only when RSHClO reacted with biothiols before reacting with hypochlorous acid, a phenomenon that has been confirmed in aqueous solutions and cells. This feature enables the probe to mimic biological processes and is particularly suitable for imaging oxidizing and reducing substances that cannot coexist.

