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Trace elements-based Auroshell gold@hematite nanostructure: Green synthesis and their hyperthermia therapy.
Hadil M Alahdal1, Sumya Ayad Abdullrezzaq2, Hawraz Ibrahim M Amin3,4
1Department of Biology, College of Science, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia.
IET Nanobiotechnology
|November 24, 2022
Summary
Green synthesized iron/gold Auroshell nanoparticles demonstrate minimal toxicity and safe application against normal cells. These nanoparticles offer efficient hyperthermia for glioblastoma cancer treatment by enabling targeted tumor heating.
Area of Science:
- Biotechnology
- Nanotechnology
- Materials Science
Background:
- Hyperthermia is an effective adjunct to radiation/chemotherapy, enhancing patient survival without adverse effects.
- Auroshell nanoparticles are recognized for their precise thermal control in medical applications.
- Iron/gold Auroshell nanoparticles offer potential for targeted cancer therapy.
Purpose of the Study:
- To synthesize iron/gold Auroshell nanoparticles using a green nanotechnology approach.
- To characterize the synthesized nanoparticles and evaluate their cytotoxicity.
- To assess the efficacy of these nanoparticles in hyperthermia treatment for glioblastoma cancer cells.
Main Methods:
- Green synthesis of Auroshell gold@hematite nanoparticles using rosemary extract.
- Characterization using X-ray powder diffraction, SEM, HR-TEM, and XPS.
- Cytotoxicity evaluation via MTT assay, water bath hyperthermia, and combined nano-therapy.
Main Results:
- Auroshell gold@hematite nanoparticles exhibited minimal toxicity towards normal HUVEC cells.
- The gold shell on the magnetite core ensured environmental and cellular biocompatibility.
- Targeted delivery to tumor tissue resulted in uniform heating of malignant tumors.
Conclusions:
- Green synthesized Auroshell nanoparticles are biocompatible and safe for normal cells.
- These magnetic nanoparticles are effective therapeutic agents for targeted hyperthermia in glioblastoma.
- The study highlights the potential of Auroshell nanoparticles in advanced cancer treatment strategies.
