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Implementing Patch Clamp and Live Fluorescence Microscopy to Monitor Functional Properties of Freshly Isolated PKD Epithelium
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Regulation of PKD2 channel function by TACAN

Xiong Liu1, Rui Zhang2, Mohammad Fatehi3

  • 1Membrane Protein Disease Research Group, Department of Physiology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.

The Journal of Physiology
|November 24, 2022
PubMed
Summary

TACAN protein inhibits the function of polycystic kidney disease 2 (PKD2) channel activity and mediates mechanosensitivity. This interaction reveals TACAN as a PKD2 inhibitor, impacting kidney disease progression.

Keywords:
CRISPR/Cas9TMEM120AXenopus oocyteautosomal dominant polycystic kidney diseaseelectrophysiologymammalian cellmechanosensitivityzebrafish

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