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Updated: Aug 20, 2025

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
[From Sherlock Holmes to Dr House. Analogies between medical thought and investigative method.]
Abstract:
The analogies between clinical method and science of investigation are present in great measure in literature. Both the doctor and the detective have, as the main purpose of their action, the identification of the culprit of an abnormal and dangerous situation (the diagnosis of the disease on the one hand, the identification of the criminal on the other). Hence the idea of proposing the prototype of the modern investigator, Sherlock Holmes, as a travel companion in evidence-based medicine. Deduction, induction and abduction: these are the means available to investigators and doctors to solve the cases that arise before them.
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