Related Experiment Video

Updated: Aug 20, 2025

Author Spotlight: Investigating the Potential of Chinese Herbal Medicinal Active Dioscin in Treating IgA Nephropathy
14:18

Author Spotlight: Investigating the Potential of Chinese Herbal Medicinal Active Dioscin in Treating IgA Nephropathy

Published on: October 13, 2023

1.9K

Related factors of crescents and prognosis in IgA nephropathy

Feng Yi, Zuhai Li, Jun Jiang

    Clinical Nephrology
    |November 24, 2022
    PubMed

    Insights

    IgA nephropathy (IgAN) patients with crescents show more severe symptoms and poorer kidney prognosis. Crescents and platelet count are key predictors of IgAN progression.

    Area of Science:

    • Nephrology
    • Glomerular Diseases
    • Renal Pathology

    Background:

    • Immunoglobulin A nephropathy (IgAN) is the most common primary glomerular disease globally.
    • The role of crescents as a predictor of renal prognosis in IgAN remains debated.
    • Further research is needed to clarify the significance of crescents in IgAN patients.

    Purpose of the Study:

    • To investigate the clinical and pathological factors associated with crescents in IgAN.
    • To evaluate the prognostic value of crescents for renal function in IgAN patients.

    Main Methods:

    • 178 IgAN patients were classified into non-crescent (C0) and crescent (C1, C2) groups based on biopsy findings.
    • Clinical data, renal pathology indexes, proteinuria, and renal function were compared and followed up.
    • Logistic and Cox regression analyses were used to identify risk factors and assess prognosis.

    Main Results:

    • Crescent groups (C1, C2) exhibited lower serum albumin, hemoglobin, C3, and IgA complements, with higher 24-hour urine protein and erythrocyte counts compared to C0.
    • Hemoglobin and C3 complement deposition were independent factors related to crescents.
    • Higher crescent proportion (≥25%) and elevated platelet count were associated with significantly worse renal survival and progression to end-stage renal disease.

    Conclusions:

    • IgAN patients with crescents present with more severe clinical manifestations and a poorer renal prognosis.
    • The presence of crescents and elevated serum platelet count are significant risk predictors for adverse outcomes in IgAN.
    Abstract

    More Related Videos

    Glomerular Outgrowth as an Ex Vivo Assay to Analyze Pathways Involved in Parietal Epithelial Cell Activation06:39

    Glomerular Outgrowth as an Ex Vivo Assay to Analyze Pathways Involved in Parietal Epithelial Cell Activation

    Published on: August 19, 2020

    5.7K
    Detection of MicroRNA Expression in the Kidneys of Immunoglobulin A Nephropathic Mice05:39

    Detection of MicroRNA Expression in the Kidneys of Immunoglobulin A Nephropathic Mice

    Published on: July 8, 2020

    1.9K

    Related Concept Videos

    Nephrotic Syndrome I : Introduction01:24

    Nephrotic Syndrome I : Introduction

    Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
    18
    Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

    Acute Kidney Injury IV: Diagnostic Studies and Prevention

    Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
    53
    Nephrotic Syndrome III : Nursing Management01:24

    Nephrotic Syndrome III : Nursing Management

    Nursing management for nephrotic syndrome adapts as the disease progresses, with strategies evolving to address advancing symptoms and complications.Early-Stage Management In the early stages, nursing interventions for nephrotic syndrome resemble those used in managing acute glomerulonephritis, focusing on symptom monitoring, fluid balance, and managing mild to moderate edema.Vital Signs: Regularly monitor blood pressure, pulse, respiratory rate, and temperature to promptly identify...
    26
    Acute Kidney Injury III: Clinical Manifestations01:29

    Acute Kidney Injury III: Clinical Manifestations

    Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
    59
    Chronic Kidney Disease III: Interprofessional Care01:28

    Chronic Kidney Disease III: Interprofessional Care

    Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
    70
    Nephrotic Syndrome II : Assessment and Medical Management01:26

    Nephrotic Syndrome II : Assessment and Medical Management

    IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
    16