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Updated: Aug 20, 2025

Fully Endoscopic Mitral Valve Repair with Percutaneous Cannulation of Groin Vessels
Published on: May 26, 2023
Procedural complications associated with percutaneous mitral balloon valvotomy: A systematic review
Haroon Rashid1, Zargham Ul Haq2, Shafiq Alam3
1Department of Critical Care, Wythenshawe Hospital, Manchester, England.
Background:
As Percutaneous mitral balloon valvotomy (PMBV) remains the keystone in treating mitral stenosis, we conducted this review to elucidate the cumulative frequency and predictors of complications following PMBV and their occurrence in various patient populations.
Areas Covered:
We searched digital databases for relevant studies covering complications of PMBV and retrieved articles using the Medical Subject Heading (MeSH) keywords.
Expert Opinion:
A total of 37 articles (8 RCTs, 7 nonrandomized clinical trials, 22 observational studies) were selected for qualitative analysis. A total of 11,803 patients undergoing PMBV among 37 studies were included, with a mean success rate of 84.54%. The most common complication was mitral regurgitation (8.2%) followed by an atrial septal defect (2.4%). Other relevant complications like stroke, pericardial tamponade, rupture of mitral leaflets, and conduction abnormalities were present in <1% of the patients.
Insights
Percutaneous mitral balloon valvotomy (PMBV) is effective for mitral stenosis, with common complications including mitral regurgitation and atrial septal defects. Other serious adverse events are rare.
Area of Science:
- Cardiology
- Interventional Cardiology
- Medical Reviews
Background:
- Percutaneous mitral balloon valvotomy (PMBV) is a primary treatment for mitral stenosis.
- Understanding PMBV complication rates and predictors is crucial for patient care.
- This review synthesizes data on PMBV complications across diverse patient groups.
Approach:
- A comprehensive literature search was performed using Medical Subject Headings (MeSH) and digital databases.
- 37 studies, including RCTs and observational trials, were analyzed qualitatively.
- Data from 11,803 patients undergoing PMBV were included.
Key Points:
- The overall success rate for PMBV was 84.54%.
- Mitral regurgitation (8.2%) and atrial septal defect (2.4%) were the most frequent complications.
- Severe complications such as stroke, pericardial tamponade, and leaflet rupture occurred in less than 1% of patients.
Conclusions:
- PMBV demonstrates a high success rate in treating mitral stenosis.
- Mitral regurgitation is the most common complication, necessitating careful monitoring.
- The incidence of severe complications is low, supporting PMBV's safety profile.
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