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3D-Printing for Critical Sized Bone Defects: Current Concepts and Future Directions
Cory K Mayfield1, Mina Ayad1, Elizabeth Lechtholz-Zey1
1Department of Orthopaedic Surgery, Keck School of Medicine of USC, Los Angeles, CA 90033, USA.
Bioengineering (Basel, Switzerland)
|November 24, 2022
Summary
Segmental bone defects pose challenges in orthopaedic surgery. Three-dimensional (3D) printing offers a promising solution for bone regeneration by optimizing scaffold design and incorporating biologics.
Area of Science:
- Orthopaedic Surgery
- Biomaterials Engineering
- Regenerative Medicine
Background:
- Segmental bone defects from trauma, non-union, or surgery present significant clinical challenges.
- Current treatments for large bone defects have limitations in achieving consistent, satisfactory outcomes.
Purpose of the Study:
- To review current strategies for managing segmental bone loss in orthopaedics.
- To highlight the potential of three-dimensional (3D) printing in addressing these defects.
Main Methods:
- Review of existing literature on bone defect management, including graft selection and substitutes.
- Exploration of three-dimensional (3D) printing technologies and their application in orthopaedics.
Main Results:
- Current methods for bone defect management are being advanced by novel strategies.
- Three-dimensional (3D) printing shows significant potential for creating customized scaffolds for bone regeneration.
Conclusions:
- Optimization of 3D-printed scaffolds through material, design, and biologic additives can enhance bone regeneration.
- 3D printing may revolutionize the treatment paradigm for challenging segmental bone defects.
