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Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
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Stem Cell Culture01:17

Stem Cell Culture

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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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iPS Cell Differentiation01:22

iPS Cell Differentiation

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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
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Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
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EPS and iPS Cells in Disease Research01:21

EPS and iPS Cells in Disease Research

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Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
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Related Experiment Video

Updated: Aug 20, 2025

Intra-Arterial Delivery of Neural Stem Cells to the Rat and Mouse Brain: Application to Cerebral Ischemia
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Stem Cell- and Cell-Based Therapies for Ischemic Stroke.

Delia Carmen Nistor-Cseppentö1, Maria Carolina Jurcău2, Anamaria Jurcău1

  • 1Department of Psycho-Neurosciences and Rehabilitation, Faculty of Medicine and Pharmacy, University of Oradea, 410087 Oradea, Romania.

Bioengineering (Basel, Switzerland)
|November 24, 2022
PubMed
Summary

Stem cell therapy offers promising neurorestorative potential for stroke survivors, with mesenchymal stem cells and extracellular vesicles showing advantages. Ongoing clinical trials aim to optimize delivery and efficacy for improved stroke recovery outcomes.

Keywords:
clinical trialsexosomesextracellular vesiclesischemic strokemesenchymal stem cellsmiRNAsneural stem cellsneuroregeneration

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Intra-Arterial Delivery of Neural Stem Cells to the Rat and Mouse Brain: Application to Cerebral Ischemia
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Intracerebral Transplantation and In Vivo Bioluminescence Tracking of Human Neural Progenitor Cells in the Mouse Brain
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Area of Science:

  • Neuroscience
  • Regenerative Medicine
  • Biotechnology

Background:

  • Stroke is a leading cause of global disability, with significant unmet needs for effective neurorestorative treatments.
  • Current therapies have limitations, driving research into novel approaches for stroke recovery.
  • Stem cells offer multifaceted therapeutic mechanisms, including cell replacement, trophic factor secretion, and immunomodulation.

Purpose of the Study:

  • To review the potential of stem cell-based therapies for stroke.
  • To compare different types of stem cells and their delivery methods.
  • To discuss challenges and future directions in stem cell therapy for ischemic stroke.

Main Methods:

  • Review of current literature on stem cell applications in stroke.
  • Comparison of neural stem cells versus mesenchymal stem cells.
  • Discussion of extracellular vesicles and exosomes as cell-free therapeutic alternatives.
  • Analysis of clinical trial progress and challenges.

Main Results:

  • Mesenchymal stem cells offer advantages in terms of immunogenicity and accessibility compared to neural stem cells.
  • Extracellular vesicles and exosomes present a promising cell-free approach with engineering potential.
  • Stem cell therapies for stroke have entered clinical trials, demonstrating safety but requiring further efficacy validation.
  • Optimization of timing, dosage, and delivery is crucial for therapeutic success.

Conclusions:

  • Stem cell and cell-based therapies hold significant promise for treating ischemic stroke.
  • Further research and clinical trials are needed to establish optimal protocols and confirm efficacy.
  • Advancements in stem cell technology and delivery systems are expected to improve outcomes for stroke patients.