The Impact of Obesity on C1q/TNF-Related Protein-9 Expression and Endothelial Function following Acute High-Intensity
Brandon G Fico1, Ryan S Garten2, Michael C Zourdos3
1Department of Kinesiology, University of Wisconsin-Madison, Madison, WI 53706, USA.
Biology
|November 24, 2022
Summary
High-intensity interval exercise and continuous moderate-intensity exercise both increase C1q-TNF-related protein-9 (CTRP9). Continuous moderate-intensity exercise showed a greater improvement in endothelial function in obese individuals.
Area of Science:
- Cardiovascular Physiology
- Metabolic Health
- Exercise Science
Background:
- C1q-TNF-related protein-9 (CTRP9) plays a role in endothelial function by increasing nitric oxide synthase and reducing vasoconstrictors.
- Limited research exists on how exercise influences CTRP9 levels, particularly in individuals with obesity.
Purpose of the Study:
- To compare the effects of high-intensity interval exercise (HIIE) and continuous moderate-intensity exercise (CME) on CTRP9 levels and flow-mediated dilation (FMD) in obese participants.
- To investigate the relationship between CTRP9 and endothelial function following different exercise protocols.
Main Methods:
- Sixteen young males (9 obese, 7 normal-weight) underwent counterbalanced, calorically-equated HIIE and CME protocols.
- Serum CTRP9 and FMD were measured pre-exercise, immediately post-exercise, and at 1 and 2 hours into recovery.
Main Results:
- Both HIIE and CME significantly increased CTRP9 immediately after exercise in all participants (p=0.003).
- Obese participants exhibited a greater CME-induced FMD response at 2 hours post-exercise (p=0.009).
- A positive correlation was found between CTRP9 and FMD percent change during CME in combined participant groups (r=0.589, p=0.016).
Conclusions:
- Acute HIIE and CME effectively increase CTRP9 in young males, irrespective of weight status.
- CME may offer superior benefits for endothelial function recovery in obese individuals compared to HIIE.
- CTRP9 may be a contributing factor to exercise-mediated improvements in endothelial function, particularly with CME.
Keywords:
C1q-TNF-related protein-9endothelial functionflow-mediated dilationhigh-Intensity interval exerciseobesityMore Related Videos
Related Concept Videos
01:20Exercise and Cardiovascular Response
1.0K
Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
1.0K
01:24Obesity
581
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
581