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Predicting Eye and Hair Color in a Turkish Population Using the HIrisPlex System
Ilksen Sari O1,2, Sumeyye Zulal Simsek1, Gonul Filoglu1
1Institute of Forensic Sciences and Legal Medicine, Istanbul University-Cerrahpasa, 34500 Istanbul, Turkey.
Genes
|November 24, 2022
Summary
Forensic DNA Phenotyping using the HIrisPlex system accurately predicts eye and hair color in the Turkish population. Careful interpretation is needed for intermediate eye and blond hair colors in casework.
Area of Science:
- Forensic Science
- Genetics
- Human Identification
Background:
- Forensic DNA Phenotyping (FDP) aids in identifying individuals from crime scene DNA.
- The HIrisPlex system predicts eye and hair color, but requires population-specific validation.
Purpose of the Study:
- To evaluate the HIrisPlex system's accuracy for eye and hair color prediction in the Turkish population.
- To assess FDP's utility in Turkish forensic casework.
Main Methods:
- Tested 149 Turkish individuals using the HIrisPlex system and SNaPshot chemistry.
- Utilized the HIrisPlex online tool for predictions.
- Assessed accuracy using AUC, sensitivity, specificity, PPV, and NPV.
Main Results:
- High accuracy for blue (100%) and brown (95.60%) eyes, and black (95.23%) and brown (98.94%) hair.
- Challenges noted in predicting intermediate eye color (25% of cohort) and blond hair (40.7% misprediction).
Conclusions:
- The HIrisPlex system is applicable to Turkish forensic casework.
- Careful interpretation is essential, especially for intermediate eye and blond hair colors.
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