Related Experiment Video
Updated: Aug 20, 2025
09:37
A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging
Published on: July 14, 2016
8.4K
Mapping Genetics and Epigenetics to Explore the Pathways beyond the Correlated Ageing Phenotype
Abdelaziz Ghanemi1,2, Mayumi Yoshioka2, Jonny St-Amand1,2
1Department of Molecular Medicine, Faculty of Medicine, Laval University, Québec, QC G1V 0A6, Canada.
Genes
|November 24, 2022
Summary
Understanding the genetic and epigenetic factors driving biological ageing is crucial for developing better geriatric therapies. This study explores these molecular pathways to optimize healthcare for an ageing population.
Area of Science:
- Gerontology and Molecular Biology
- Genetics and Epigenetics of Ageing
Background:
- Ageing is a natural decline in biological functions, increasing disease risk and challenging healthcare systems.
- Modern societies face demographic shifts towards older populations, necessitating advanced geriatric care strategies.
Purpose of the Study:
- To investigate the genetic and epigenetic patterns associated with the ageing process.
- To correlate these molecular patterns with ageing-related phenotypes.
- To establish mechanistic links and map molecular pathways involved in ageing.
Main Methods:
- Exploration of genetic markers related to ageing.
- Analysis of epigenetic modifications influencing biological functions.
- Correlation studies between molecular data and observable ageing phenotypes.
Main Results:
- Identification of specific genetic and epigenetic signatures linked to ageing.
- Establishment of correlations between molecular patterns and physiological decline.
- Mapping of key molecular pathways implicated in the ageing process.
Conclusions:
- Understanding genetic and epigenetic factors is key to optimizing therapies for an ageing population.
- Mechanistic links between molecular pathways and ageing phenotypes have significant implications for research and clinical practice.
- This research provides a foundation for developing targeted therapeutic interventions for age-related diseases.
Related Concept Videos
01:28Human Genetics
668
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...
668
01:46Epigenetic Regulation
31.3K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
31.3K
01:09Epistasis Analysis
5.1K
Although Mendel chose seven unrelated traits in peas to study gene segregation, most traits involve multiple gene interactions that create a spectrum of phenotypes. When the interaction of various genes or alleles at different locations influences a phenotype, this is called epistasis. Epistasis often involves one gene masking or interfering with the expression of another (antagonistic epistasis). Epistasis often occurs when different genes are part of the same biochemical pathway. The...
5.1K
01:26Aging
148
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
148
02:27Background and Environment Affect Phenotype
6.7K
Although the genetic makeup of an organism plays a major role in determining the phenotype, there are also several environmental factors, such as temperature, oxygen availability, presence of mutagens, that can alter an organism’s phenotype.
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
6.7K
02:41Telomeres and Telomerase
5.3K
5.3K