Neuromorphic-Based Neuroprostheses for Brain Rewiring: State-of-the-Art and Perspectives in Neuroengineering

Area of Science:

• Neuroengineering
• Neuroprosthetics
• Biomedical Devices

Background:

• Neuroprostheses typically restore sensory/motor functions.
• Emerging devices target direct brain-level intervention.
• Next-generation devices require enhanced brain repair capabilities.

Purpose of the Study:

• To review the first real-time hardware neuromorphic prosthesis.
• To explore technological improvements for neural signal processing.
• To discuss innovative neuroprosthetics for translational research.

Main Methods:

• Review of a case study on a real-time hardware neuromorphic prosthesis.
• Analysis of closed-loop systems with neuromorphic elements.
• Discussion of technological advancements in neural interfacing.

Main Results:

• Demonstrated bidirectional communication between neuronal populations in vitro.
• Highlighted the potential of neuromorphic elements for energy efficiency and real-time processing.
• Presented perspectives on novel in vitro and in vivo experimental designs.

Conclusions:

• Neuromorphic-based closed-loop neuroprostheses are crucial for next-generation brain repair.
• These systems offer improved synergy between technological and biological components.
• Advancements may lead to 'brain-prostheses' capable of rewiring or substituting injured nervous systems.