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Published on: November 9, 2016
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Commercially Available Enteric Empty Hard Capsules, Production Technology and Application.
Aleš Franc1, David Vetchý1, Nicole Fülöpová1
1Department of Pharmaceutical Technology, Faculty of Pharmacy, Masaryk University, 612 42 Brno, Czech Republic.
Pharmaceuticals (Basel, Switzerland)
|November 24, 2022
Summary
Enteric capsule drug delivery technology (ECDDT) offers a solution for protecting acid-sensitive substances like probiotics and fecal material. This review examines various enteric capsules for individual therapy and clinical use.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Systems
- Gastroenterology
Background:
- Growing need for small-batch enteric capsules for individual therapy and clinical trials.
- Acid-sensitive substances, including probiotics and fecal material for fecal microbiota transplantation (FMT), require protection from stomach acidity.
- Enteric Capsule Drug Delivery Technology (ECDDT) offers a promising encapsulation method.
Purpose of the Study:
- To review the composition and properties of commercially available hard enteric capsules.
- To evaluate their suitability for delivering acid-sensitive substances via ECDDT.
- To provide insights into practical applications despite potential limitations in pharmaceutical testing.
Main Methods:
- Literature review of existing studies on enteric capsules and ECDDT.
- Analysis of capsule compositions, including pH-soluble and gelling polymers.
- Examination of properties relevant to delayed-release dosage forms.
Main Results:
- Commercial enteric capsules (e.g., AR Caps®, EnTRinsic™, Vcaps® Enteric, DRcaps®, EMBO CAPS® AP, BioVXR®, ACGcaps™ HD) utilize pH-soluble or gelling polymers.
- These capsules are suitable for encapsulating drugs or biological suspensions for targeted delivery.
- While not all formulations meet stringent pharmaceutical delayed-release criteria, they demonstrate practical utility.
Conclusions:
- ECDDT provides a viable approach for preparing enteric capsules for specialized applications like FMT.
- Understanding capsule composition and properties is crucial for optimizing drug and biological material delivery.
- Further research may be needed to fully characterize and optimize ECDDT formulations for pharmaceutical requirements.
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