Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

179
Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
179
Drug Delivery: Enteral Route01:18

Drug Delivery: Enteral Route

616
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
616
Endoscopic Procedures III: Video Capsule Endoscopy01:28

Endoscopic Procedures III: Video Capsule Endoscopy

310
Capsule endoscopy, or wireless or video capsule endoscopy, is a diagnostic procedure for examining the entire gastrointestinal tract. Patients swallow a capsule about the size of a vitamin tablet. The capsule is equipped with a transmitter, a battery, an LED light source, and a color video camera to capture images throughout the gastrointestinal tract. This procedure is particularly useful for diagnosing conditions such as Crohn's disease, ulcerative colitis, tumors, polyps, ulcers,...
310
Routes of Drug Administration: Enteral01:18

Routes of Drug Administration: Enteral

4.1K
Medications can be administered through the enteral route using liquids, capsules, or tablets.
Enteral administration involves drug administration via the mouth in two ways: orally or sublingually.
Unlike sublingually drugs, drugs that are taken orally pass through the gastrointestinal (GI) tract and get metabolized by the liver. Once metabolized, the drug is absorbed into the systemic circulation, reaching different body parts via the bloodstream. However, while passing through the stomach,...
4.1K
Drug Delivery: Parenteral Route01:29

Drug Delivery: Parenteral Route

739
The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
739
Methods for Studying Drug Absorption: In vitro01:16

Methods for Studying Drug Absorption: In vitro

288
In vitro experiments are crucial for understanding the transport and absorption of drugs through biological materials. These studies employ varied methods such as the diffusion cell method, the everted sac technique, and the everted ring technique.
The diffusion cell method uses a two-compartment cell, including a donor compartment with the drug solution, which simulates the environment where the drug is applied, and a receptor compartment with a buffer solution, which simulates the environment...
288

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Phytotherapeutics self-microemulsifying systems in pellet dosage form for enhanced intestinal drug delivery: formulation, stability, and <i>in-vivo</i> performance.

Drug delivery·2026
Same author

The effect of mepolizumab dosage form on treatment outcomes in severe asthma.

Frontiers in medicine·2025
Same author

Development and evaluation of innovative enteric-coated capsules for colon-specific delivery of hydrophilic biomaterials.

International journal of pharmaceutics·2024
Same author

Development of a New Bioequivalent Omeprazole Product.

Medicina (Kaunas, Lithuania)·2024
Same author

Effect of treatment with original or biosimilar adalimumab on SARS-CoV2 vaccination antibody titers.

International journal of pharmaceutics: X·2024
Same author

Preparation and Evaluation of a Dosage Form for Individualized Administration of Lyophilized Probiotics.

Pharmaceutics·2023

Related Experiment Video

Updated: Aug 20, 2025

Extraction of Plant-based Capsules for Microencapsulation Applications
10:54

Extraction of Plant-based Capsules for Microencapsulation Applications

Published on: November 9, 2016

12.1K

Commercially Available Enteric Empty Hard Capsules, Production Technology and Application.

Aleš Franc1, David Vetchý1, Nicole Fülöpová1

  • 1Department of Pharmaceutical Technology, Faculty of Pharmacy, Masaryk University, 612 42 Brno, Czech Republic.

Pharmaceuticals (Basel, Switzerland)
|November 24, 2022
PubMed
Summary

Enteric capsule drug delivery technology (ECDDT) offers a solution for protecting acid-sensitive substances like probiotics and fecal material. This review examines various enteric capsules for individual therapy and clinical use.

Keywords:
ECDDT technologyacid resistancecommercial capsulesencapsulationenteric administrationhard capsules

More Related Videos

Author Spotlight: Advancing Cell Therapy Manufacturing with Dissolvable Microcarriers
09:44

Author Spotlight: Advancing Cell Therapy Manufacturing with Dissolvable Microcarriers

Published on: July 7, 2023

3.5K
Encapsulated Cell Technology for the Delivery of Biologics to the Mouse Eye
06:10

Encapsulated Cell Technology for the Delivery of Biologics to the Mouse Eye

Published on: March 30, 2020

6.7K

Related Experiment Videos

Last Updated: Aug 20, 2025

Extraction of Plant-based Capsules for Microencapsulation Applications
10:54

Extraction of Plant-based Capsules for Microencapsulation Applications

Published on: November 9, 2016

12.1K
Author Spotlight: Advancing Cell Therapy Manufacturing with Dissolvable Microcarriers
09:44

Author Spotlight: Advancing Cell Therapy Manufacturing with Dissolvable Microcarriers

Published on: July 7, 2023

3.5K
Encapsulated Cell Technology for the Delivery of Biologics to the Mouse Eye
06:10

Encapsulated Cell Technology for the Delivery of Biologics to the Mouse Eye

Published on: March 30, 2020

6.7K

Area of Science:

  • Pharmaceutical Sciences
  • Drug Delivery Systems
  • Gastroenterology

Background:

  • Growing need for small-batch enteric capsules for individual therapy and clinical trials.
  • Acid-sensitive substances, including probiotics and fecal material for fecal microbiota transplantation (FMT), require protection from stomach acidity.
  • Enteric Capsule Drug Delivery Technology (ECDDT) offers a promising encapsulation method.

Purpose of the Study:

  • To review the composition and properties of commercially available hard enteric capsules.
  • To evaluate their suitability for delivering acid-sensitive substances via ECDDT.
  • To provide insights into practical applications despite potential limitations in pharmaceutical testing.

Main Methods:

  • Literature review of existing studies on enteric capsules and ECDDT.
  • Analysis of capsule compositions, including pH-soluble and gelling polymers.
  • Examination of properties relevant to delayed-release dosage forms.

Main Results:

  • Commercial enteric capsules (e.g., AR Caps®, EnTRinsic™, Vcaps® Enteric, DRcaps®, EMBO CAPS® AP, BioVXR®, ACGcaps™ HD) utilize pH-soluble or gelling polymers.
  • These capsules are suitable for encapsulating drugs or biological suspensions for targeted delivery.
  • While not all formulations meet stringent pharmaceutical delayed-release criteria, they demonstrate practical utility.

Conclusions:

  • ECDDT provides a viable approach for preparing enteric capsules for specialized applications like FMT.
  • Understanding capsule composition and properties is crucial for optimizing drug and biological material delivery.
  • Further research may be needed to fully characterize and optimize ECDDT formulations for pharmaceutical requirements.