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A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks
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Is Hepatitis E Virus a Neglected or Emerging Pathogen in Egypt?

Ibrahim M Sayed1,2, Sayed F Abdelwahab3

  • 1Department of Biomedical and Nutritional Sciences, University of Massachusetts Lowell, Lowell, MA 01854, USA.

Pathogens (Basel, Switzerland)
|November 24, 2022
PubMed
Summary

Hepatitis E virus (HEV) is a significant threat in Egypt, with high seropositivity rates, especially in rural areas. Despite its prevalence, HEV infection is often undiagnosed, necessitating urgent preventive measures.

Keywords:
EgyptHEVemerging pathogenneglectedwaterzoonoses

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Area of Science:

  • Hepatology
  • Infectious Diseases
  • Public Health

Background:

  • Egypt faces a high burden of viral hepatitis and liver disease.
  • Hepatitis E virus (HEV) remains a neglected pathogen despite its prevalence.

Purpose of the Study:

  • To highlight the significant public health threat posed by Hepatitis E virus in Egypt.
  • To underscore the need for improved diagnostics and preventive strategies for HEV infection.

Main Methods:

  • Review of existing data on HEV prevalence, risk factors, and clinical manifestations in Egypt.
  • Analysis of seropositivity rates and diagnostic challenges.

Main Results:

  • HEV seropositivity in Egyptian villagers ranges from 60-80%, particularly in children.
  • Risk factors include poor sanitation, well water, and animal contact.
  • HEV infection is often subclinical but can lead to fulminant hepatic failure.
  • HEV is frequently undiagnosed in Egyptian hospitals despite high seroprevalence.

Conclusions:

  • Hepatitis E virus represents a substantial and underestimated threat to public health in Egypt.
  • Enhanced surveillance, routine diagnosis, and targeted preventive measures are crucial to mitigate HEV infection and its complications.