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The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
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The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
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Monkeypox and Pregnancy: Latest Updates.

Alexandre Cuérel1, Guillaume Favre1, Manon Vouga1

  • 1Department Woman-Mother-Child, Lausanne University Hospital and University of Lausanne, 1011 Lausanne, Switzerland.

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|November 24, 2022
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Summary
This summary is machine-generated.

Monkeypox virus (MPXV) is a growing zoonotic threat, with 2022 seeing a rapid global spread. More research is needed on MPXV pregnancy risks for mothers and fetuses to develop evidence-based guidelines.

Keywords:
deliverymiscarriagemonkeypoxorthopoxpregnancysmallpoxvaccinevertical transmission

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Area of Science:

  • Virology
  • Public Health
  • Obstetrics

Background:

  • Monkeypox virus (MPXV) poses a significant zoonotic threat, with rapid global spread observed recently, particularly in 2022.
  • The factors contributing to this accelerated transmission are complex and likely multifactorial.
  • While a large-scale pandemic is improbable due to low R0 values, genetic analysis of the 2022 MPXV strain suggests potential accelerated human adaptation.

Purpose of the Study:

  • To summarize current knowledge regarding MPXV infections.
  • To review the risks associated with MPXV infection during pregnancy for both maternal and fetal health.
  • To identify knowledge gaps and the need for evidence-based guidelines for MPXV in pregnancy.

Main Methods:

  • Literature review of current scientific knowledge on MPXV.
  • Analysis of MPXV transmission dynamics and genetic changes.
  • Synthesis of information on viral infections during pregnancy.

Main Results:

  • MPXV has demonstrated rapid global spread in recent years, with potential indicators of human adaptation in the 2022 strain.
  • There is a significant lack of data concerning the specific risks of MPXV infection during pregnancy.
  • Existing knowledge on similar viral infections during pregnancy is limited in its applicability to MPXV.

Conclusions:

  • Further observational studies are crucial to understand MPXV's impact on pregnancy.
  • Clear, evidence-based guidelines are needed to manage MPXV infections in pregnant individuals and protect fetuses.
  • The potential for accelerated human adaptation warrants continued surveillance and research into MPXV's evolving epidemiology.