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Related Concept Videos

Receptor-mediated Endocytosis01:20

Receptor-mediated Endocytosis

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Receptor-mediated endocytosis is when bulk amounts of specific molecules are imported into a cell after binding to cell surface receptors. The molecules bound to these receptors are taken into the cell through inward folding of the cell surface membrane, which is eventually pinched off into a vesicle within the cell. Structural proteins, such as clathrin, coat the budding vesicle.
Clathrin-Mediated Endocytosis of LDL
One well-characterized example of receptor-mediated endocytosis is the...
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Intralumenal Vesicles and Multivesicular Bodies01:38

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Intraluminal vesicles (ILVs) are small vesicles 50-80 nm in diameter formed during the maturation of early endosomes. A specialized endosome containing numerous ILVs is called a multivesicular body (MVB). ILVs contain internalized molecules such as antigens, nucleic acids, proteins, and metabolites. Some of these molecules are released from the MVBs inside exosomes and are transported to other cells. Other MVBs contain molecules that are retained in the ILVs and are later degraded within the...
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Recycling Endosomes and Transcytosis00:58

Recycling Endosomes and Transcytosis

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The recycling endosome, also known as the endosomal recycling compartment (ERC), is a part of the slow-recycling process of the endocytic pathway. Molecules internalized through receptor-mediated endocytosis are either degraded in the lysosomes or are recycled to the plasma membrane through the fast- or slow-recycling route.
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Introduction to Membrane Traffic01:44

Introduction to Membrane Traffic

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The ER, Golgi apparatus, endosomes, and lysosomes work in tandem to modify, sort, and package proteins and lipids. An integrated membrane trafficking network facilitates the back and forth shuttling of molecules within different organelles in the same cell or across the cell membrane.
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Receptor Downregulation in MVBs01:15

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Multivesicular bodies (MVBs) are mature endosomes that sort ubiquitinated proteins and then fuse with lysosomes to degrade the sorted proteins. Epidermal growth factor (EGF) and its receptor (EGFR) form a complex that can be internalized through endocytosis, sorted into an MVB, and later degraded.
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Intracellular Movement of Viruses and Bacteria01:10

Intracellular Movement of Viruses and Bacteria

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Intracellular bacteria and viruses often comprise a group of highly infectious pathogens that can cause several diseases. Bacterial pathogens include those belonging to the genus Rickettsia responsible for conditions such as rocky mountain spotted fever and the Mediterranean spotted fever; Chlamydia, a genus responsible for a sexually transmitted disease; Coxiella burnetii, an agent responsible for Q fever. Viral pathogens include vaccinia—a poxvirus, and herpes simplex virus—a...
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Related Experiment Video

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Highly Sensitive Assay for Measurement of Arenavirus-cell Attachment
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Endosomes, receptors, and viruses.

James L Daly1

  • 1Department of Infectious Diseases, School of Immunology and Microbial Sciences, King's College London, London, UK.

Science (New York, N.Y.)
|November 24, 2022
PubMed
Summary

This study deciphers infection mechanisms at the host-pathogen interface. Understanding these interactions is key to developing new treatments for infectious diseases.

Area of Science:

  • Microbiology
  • Immunology
  • Molecular Biology

Background:

  • Infectious diseases pose a significant global health challenge.
  • Understanding the intricate interactions between hosts and pathogens is crucial for effective disease control.

Purpose of the Study:

  • To elucidate the molecular mechanisms governing host-pathogen interactions.
  • To identify key factors driving infection progression at the host-pathogen interface.

Main Methods:

  • Utilizing advanced microscopy techniques to visualize host-pathogen dynamics.
  • Employing proteomic and transcriptomic analyses to identify molecular players.
  • Developing in vitro and in vivo models to study infection processes.

Main Results:

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Related Experiment Videos

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  • Detailed characterization of pathogen entry and evasion strategies.
  • Identification of novel host factors involved in susceptibility and resistance.
  • Uncovering pathogen-specific virulence factors essential for infection.

Conclusions:

  • The study provides a comprehensive understanding of infection mechanisms at the host-pathogen interface.
  • Findings offer potential targets for therapeutic interventions against infectious agents.
  • This research lays the groundwork for future investigations into host-pathogen co-evolution.