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Echocardiographic Approaches and Protocols for Comprehensive Phenotypic Characterization of Valvular Heart Disease in Mice
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Visualizing diastolic failure: Non-invasive imaging-biomarkers in patients with heart failure with preserved ejection

Alexander Schulz1, Andreas Schuster1

  • 1Department of Cardiology and Pneumology, Georg-August University, University Medical Center Göttingen, Göttingen, Germany.

Ebiomedicine
|November 24, 2022
PubMed

Insights

Heart failure with preserved ejection fraction (HFpEF) is a growing medical challenge. Novel non-invasive imaging techniques offer promising insights into diastolic dysfunction, improving diagnosis and patient outcomes.

Area of Science:

  • Cardiology
  • Medical Imaging

Background:

  • Heart failure with preserved ejection fraction (HFpEF) presents a significant clinical challenge.
  • Invasive right heart catheterization is the standard for diagnosing diastolic dysfunction but carries risks.
  • Non-invasive diagnostic methods are increasingly sought for HFpEF management.

Purpose of the Study:

  • To explore advanced, non-invasive imaging modalities for diagnosing HFpEF.
  • To highlight the incremental value of novel techniques in understanding HFpEF.
  • To review recent findings on prognostication and therapy monitoring using these methods.

Main Methods:

  • Review of current literature on non-invasive cardiac imaging for HFpEF.
  • Inclusion of transthoracic echocardiography, cardiac MRI, CT, PET, and SPECT.
  • Analysis of diagnostic and prognostic capabilities of each modality.

Main Results:

  • Novel imaging techniques provide deeper insights into HFpEF pathophysiology.
  • These methods show promise in enhancing diagnostic accuracy beyond traditional approaches.
  • Emerging data suggest improved prognostication and therapy monitoring capabilities.

Conclusions:

  • Advanced imaging techniques are crucial for a comprehensive understanding of HFpEF.
  • Non-invasive methods offer valuable alternatives to invasive procedures for HFpEF diagnosis.
  • These sophisticated tools may guide targeted therapies and improve patient outcomes.

Keywords:
Diastolic dysfunctionHFpEFImaging markersNon-invasive imaging

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