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Relation between macrophage inflammatory protein-1 and intercellular adhesion molecule-1 and computed tomography
Aljohara Mohmoud Hamza1, Warda Demerdash Khalifa Ali2, Nagwa Hassanein3
1Department of Anesthesia, Princess Nourah Bint Abdulrahman University, Kingdom of Saudi Arabia.
Insights
Macrophage inflammatory protein-1 alpha (MIP-1α) and intracellular adhesion molecule 1 (ICAM-1) levels correlate with COVID-19 severity. Higher levels indicate more severe CT findings and inflammatory markers, suggesting prognostic value.
Area of Science:
- Immunology
- Virology
- Radiology
Background:
- COVID-19 severity is linked to various clinical and biochemical factors.
- Macrophage inflammatory protein-1 alpha (MIP-1α) is a chemokine involved in cell adhesion and migration.
- Intracellular adhesion molecule 1 (ICAM-1) is an immune-involved cell adhesion molecule.
Purpose of the Study:
- To investigate the association between baseline serum MIP-1α and ICAM-1 levels in critically-ill COVID-19 patients.
- To correlate these marker levels with the severity of computed tomography (CT) findings in COVID-19 patients.
Main Methods:
- Included 100 critically-ill COVID-19 patients diagnosed via RT-PCR.
- Measured serum MIP-1α and ICAM-1 levels using ELISA kits.
- Assessed pulmonary involvement severity using high-resolution CT scans.
Main Results:
- Severe CT findings were associated with significantly higher MIP-1α and ICAM-1 levels.
- MIP-1α positively correlated with age, D-dimer, and IL6; inversely with INF-alpha.
- ICAM-1 positively correlated with age, D-dimer, TNF-α, and IL6; inversely with INF-alpha.
Conclusions:
- Serum MIP-1α and ICAM-1 levels are related to CT-defined radiological severity in COVID-19.
- These markers correlate with other inflammatory markers, indicating their potential as prognostic indicators for COVID-19.
Background:
Several, clinical and biochemical factors were suggested as risk factors for more severe forms of Covid-19. Macrophage inflammatory protein-1 alpha (MIP-1α, CCL3) is a chemokine mainly involved in cell adhesion and migration. Intracellular adhesion molecule 1 (ICAM-1) is an inducible cell adhesion molecule involved in multiple immune processes. The present study aimed to assess the relationship between baseline serum MIP-1α and ICAM-1 level in critically-ill Covid-19 patients and the severity of computed tomography (CT) findings.
Methods:
The study included 100 consecutive critically-ill patients with Covid-19 infection. Diagnosis of infection was established on the basis of RT-PCR tests. Serum MIP-1α and ICAM-1 levels were assessed using commercially available ELISA kits. All patients were subjected to a high-resolution computed tomography assessment.
Results:
According to the computed tomography severity score, patients were classified into those with moderate/severe (n=49) and mild (n = 51) pulmonary involvement. Severe involvement was associated with significantly higher MIP-1α and ICAM-1 level. Correlation analysis identified significant positive correlations between MIP-1α and age, D-dimer, IL6, in contrast, there was an inverse correlation with INF-alpha. Additionally, ICAM-1 showed significant positive correlations with age, D-Dimer,- TNF-α, IL6,while an inverse correlation with INF-alpha was observed.
Conclusions:
MIP-1α and ICAM-1 level are related to CT radiological severity in Covid-19 patients. Moreover, these markers are well-correlated with other inflammatory markers suggesting that they can be used as reliable prognostic markers in Covid-19 patients.
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