Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Control of Power Flow01:30

Control of Power Flow

302
There are several methods to control power flow in power systems:
302
Social Facilitation01:04

Social Facilitation

32.2K
Not all intergroup interactions lead to negative outcomes. Sometimes, being in a group situation can improve performance. Social facilitation occurs when an individual performs better when an audience is watching than when the individual performs the behavior alone. This typically occurs when people are performing a task for which they are skilled.
32.2K
Turbine-Governor Control01:17

Turbine-Governor Control

344
Turbine-governor control is crucial for maintaining power system stability by balancing turbine mechanical power output with electrical load demand. This mechanism ensures that generator frequency and rotor speed are within acceptable limits during load variations. Turbine-generator units store kinetic energy due to their rotating masses; this energy is released to meet the load requirement when the load increases. The electrical torque of turbines rises to meet the demand, whereas the...
344
Bystander Effect02:09

Bystander Effect

9.6K
The discussion of bullying highlights the problem of witnesses not intervening to help a victim. This is a common occurrence, as the following well-publicized event demonstrates. In 1964, in Queens, New York, a 19-year-old woman named Kitty Genovese was attacked by a person with a knife near the back entrance to her apartment building and again in the hallway inside her apartment building. When the attack occurred, she screamed for help numerous times and eventually died from her stab wounds.
9.6K
Deindividuation00:57

Deindividuation

26.6K
Deindividuation is a form of social influence on an individual’s behavior such that the individual engages in unusual or non-normal behavior while in a group setting. Why? Because in these group settings, the individual no longer sees themselves as an individual anymore, disinhibiting their behavior and personal restraint.
26.6K
Feedback control systems01:26

Feedback control systems

378
Feedback control systems are categorized in various ways based on their design, analysis, and signal types.
Linear feedback systems are theoretical models that simplify analysis and design. These systems operate under the principle that their output is directly proportional to their input within certain ranges. For instance, an amplifier in a control system behaves linearly as long as the input signal remains within a specific range. However, most physical systems exhibit inherent nonlinearity...
378

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

De novo assembly of RNA m<sup>6</sup>A modification factors into viral genome-associated nuclear bodies drives HCMV RNA accumulation.

Cell reports·2025
Same author

Multiplexed Immunofluorescence and Single-Molecule RNA Fluorescence In Situ Hybridization in Mouse Skeletal Myofibers.

Methods in molecular biology (Clifton, N.J.)·2024
Same author

Muscleblind-like proteins use modular domains to localize RNAs by riding kinesins and docking to membranes.

Nature communications·2023
Same author

Condensation of LINE-1 is critical for retrotransposition.

eLife·2023
Same author

The myonuclear domain in adult skeletal muscle fibres: past, present and future.

The Journal of physiology·2023
Same author

Microtubule-based transport is essential to distribute RNA and nascent protein in skeletal muscle.

Nature communications·2021
Same journal

A viral ORFeome library for systems-level genetic dissection of host-pathogen interactions.

Cell·2026
Same journal

Co-option of lysosomal machinery shapes the evolution of the intracellular photosymbiosis supporting coral reefs.

Cell·2026
Same journal

LEF1 and niche factors determine T cell stemness across chronic diseases.

Cell·2026
Same journal

Recurrent patterns of TOP1-mediated neuronal genomic damage shared by major neurodegenerative disorders.

Cell·2026
Same journal

Four-dimensional molecular mapping from a spatial snapshot reveals the dynamics of hair follicle organogenesis.

Cell·2026
Same journal

Whole-cell particle-based digital twin simulations from 4D lattice light-sheet microscopy data.

Cell·2026
See all related articles

Related Experiment Video

Updated: Aug 20, 2025

Novel 3D/VR Interactive Environment for MD Simulations, Visualization and Analysis
11:29

Novel 3D/VR Interactive Environment for MD Simulations, Visualization and Analysis

Published on: December 18, 2014

12.0K

Controlling the crowd with a WNK.

Liam Joseph Holt1, Lance T Denes1

  • 1Institute for Systems Genetics, Tisch Hospital, 435 East 30th Street, New York, NY 10016, USA; Department of Biochemistry and Molecular Pharmacology at NYU Grossman School of Medicine, 435 East 30th Street, 9th Floor, Room 906, New York, NY 10016, USA.

Cell
|November 24, 2022
PubMed
Summary
This summary is machine-generated.

Cell volume control is crucial. Researchers found that increased molecular crowding triggers WNK kinase condensation, enabling cells to detect and react to volume reduction.

More Related Videos

WheelCon: A Wheel Control-Based Gaming Platform for Studying Human Sensorimotor Control
08:18

WheelCon: A Wheel Control-Based Gaming Platform for Studying Human Sensorimotor Control

Published on: August 15, 2020

5.0K
Automated Behavioral Analysis of Large C. elegans Populations Using a Wide Field-of-view Tracking Platform
07:20

Automated Behavioral Analysis of Large C. elegans Populations Using a Wide Field-of-view Tracking Platform

Published on: November 28, 2018

9.2K

Related Experiment Videos

Last Updated: Aug 20, 2025

Novel 3D/VR Interactive Environment for MD Simulations, Visualization and Analysis
11:29

Novel 3D/VR Interactive Environment for MD Simulations, Visualization and Analysis

Published on: December 18, 2014

12.0K
WheelCon: A Wheel Control-Based Gaming Platform for Studying Human Sensorimotor Control
08:18

WheelCon: A Wheel Control-Based Gaming Platform for Studying Human Sensorimotor Control

Published on: August 15, 2020

5.0K
Automated Behavioral Analysis of Large C. elegans Populations Using a Wide Field-of-view Tracking Platform
07:20

Automated Behavioral Analysis of Large C. elegans Populations Using a Wide Field-of-view Tracking Platform

Published on: November 28, 2018

9.2K

Area of Science:

  • Cell biology
  • Biochemistry
  • Molecular mechanisms

Background:

  • Cell volume regulation is a fundamental cellular process.
  • The precise mechanisms governing cell volume control have been a long-standing area of investigation.
  • Understanding how cells maintain volume is key to comprehending cellular homeostasis.

Purpose of the Study:

  • To elucidate the molecular mechanisms underlying cell volume sensing.
  • To identify key proteins involved in cellular response to volume changes.
  • To investigate the role of WNK kinase in volume regulation.

Main Methods:

  • Utilized advanced microscopy techniques to observe cellular dynamics.
  • Employed biochemical assays to analyze protein condensation.
  • Investigated cellular responses to osmotic stress and molecular crowding.

Main Results:

  • Demonstrated that increased molecular crowding directly drives the condensation of WNK kinase.
  • Showed that WNK kinase condensation is a critical event in sensing cell volume loss.
  • Established a direct link between molecular crowding, WNK kinase condensation, and cellular volume response.

Conclusions:

  • Increased molecular crowding is a key trigger for WNK kinase condensation.
  • WNK kinase condensation serves as a crucial mechanism for cells to sense and respond to volume loss.
  • This finding provides new insights into the fundamental challenge of cell volume control.