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Updated: Aug 20, 2025
Intralymphatic Immunotherapy and Vaccination in Mice
Published on: February 2, 2014
A randomised, double-blinded comparison between subcutaneous rush and intralympathic allergen immunotherapy induction
Ralf S Mueller1, Yuri Zablotski1, Katja Baumann1
1Centre for Clinical Veterinary Medicine, LMU Munich, Munich, Germany.
Background:
Atopic dermatitis (AD) is one of the most common skin diseases in small animal practice. Allergen immunotherapy (AIT) is the only curative treatment for the disease, and oral, subcutaneous and intralymphatic administration of allergens are commonly employed.
Objectives:
To compare the efficacy of AIT following an induction phase with intralymphatic injections (ILIT) or rush immunotherapy (RIT).
Animals:
Fifty privately owned dogs with AD.
Materials And Methods:
In a double-blinded study, dogs were randomly assigned to either four monthly ILIT of allergen extract or RIT with five injections administered subcutaneously at hourly intervals on the first day. They were assessed by validated scores; Canine Atopic Dermatitis Lesion Index (CADLI) and pruritus Visual Analog Scale (PVAS) at the beginning of the study and after 1, 3, 6 and 12 months. The latter were performed daily for 7 days before each revisit. Medication scores and a total clinical score were calculated and compared between each group and time point.
Results:
There was no significant difference in CADLI and PVAS scores, or CADLI and medication scores between groups at any of the time points. A significant improvement with both ILIT and RIT was seen in total and pruritus scores, respectively. An owner global assessment of good-to-excellent treatment efficacy was seen in 40% of the dogs; total scores improved by 27% and 35% in the RIT and ILIT group, respectively. Adverse effects were not seen.
Conclusions And Clinical Relevance:
Induction of AIT can be conducted either as RIT or ILIT with no loss in efficacy.
