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Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
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Correlation Between Serum Albumin and D-Dimer Levels in 909 Patients with Non-Valvular Atrial Fibrillation: A

Hua-Jing Yuan1, Xia Zhong2, Yan Li3

  • 1College of Traditional Chinese Medicine, Shandong Traditional Chinese Medicine University, Jinan, Shandong, China (mainland).

Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
|November 25, 2022
PubMed

Insights

Serum albumin levels are linked to D-dimer in atrial fibrillation (AF) patients. Lower albumin predicts higher D-dimer, suggesting albumin monitoring may help prevent blood clots in AF.

Area of Science:

  • Cardiology
  • Biochemistry

Background:

  • D-dimer levels indicate hypercoagulability in atrial fibrillation (AF) and predict thromboembolic events.
  • No effective indicator has been identified to prevent thromboembolic events in AF patients based on D-dimer levels.

Purpose of the Study:

  • To investigate the correlation between serum albumin and D-dimer levels in patients with non-valvular AF (NVAF).
  • To assess serum albumin as a potential predictor of abnormal D-dimer levels in NVAF.

Main Methods:

  • Retrospective analysis of 909 NVAF patients and 653 controls.
  • Measurement of serum albumin by colorimetry and D-dimer by latex-enhanced photoimmunoassay.
  • Correlation analysis, logistic regression, and ROC curve analysis were employed.

Main Results:

  • Both albumin and D-dimer levels were significantly associated with NVAF.
  • In NVAF patients, D-dimer levels showed a negative correlation with albumin levels (P<0.001).
  • Serum albumin was an independent risk factor and effective predictor of abnormal D-dimer levels (AUC=0.77, optimal cutoff 36.95 g/L).

Conclusions:

  • Serum albumin and D-dimer levels are significantly associated with NVAF.
  • Albumin levels are inversely correlated with D-dimer in NVAF patients.
  • Monitoring and potentially supplementing serum albumin may help prevent thromboembolic events in AF, warranting further research.

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