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Pharmacokinetic models are mathematical constructs that represent and predict the time course of drug concentrations in the body, providing meaningful pharmacokinetic parameters. These models are categorized into compartment, physiological, and distributed parameter models.
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Mechanistic models are utilized in individual analysis using single-source data, but imperfections arise due to data collection errors, preventing perfect prediction of observed data. The mathematical equation involves known values (Xi), observed concentrations (Ci), measurement errors (εi), model parameters (ϕj), and the related function (ƒi) for i number of values. Different least-squares metrics quantify differences between predicted and observed values. The ordinary least...
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One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation01:24

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This lesson introduces two critical methods in pharmacokinetics, the Wagner-Nelson and Loo-Riegelman methods, used for estimating the absorption rate constant (ka) for drugs administered via non-intravenous routes. The Wagner-Nelson method relates ka to the plasma concentration derived from the slope of a semilog percent unabsorbed time plot. However, it is limited to drugs with one-compartment kinetics and can be impacted by factors like gastrointestinal motility or enzymatic degradation.
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Related Experiment Video

Updated: Aug 20, 2025

Statistical Modelling of Cortical Connectivity Using Non-invasive Electroencephalograms
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EXTENDED STOCHASTIC BLOCK MODELS WITH APPLICATION TO CRIMINAL NETWORKS.

Sirio Legramanti1, Tommaso Rigon2, Daniele Durante1

  • 1Department Decision Sciences and Institute for Data Science and Analytics, Bocconi University.

The Annals of Applied Statistics
|November 25, 2022
PubMed
Summary

We introduce extended stochastic block models (esbm) to uncover hidden group structures in noisy network data, like criminal organizations. Our method accurately identifies complex patterns, improving network analysis and understanding.

Keywords:
Bayesian nonparametricsGibbs-type priornetworkproduct partition model

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Area of Science:

  • Network analysis
  • Statistical modeling
  • Sociology

Background:

  • Learning group structures in network data is challenging due to noise and complex patterns.
  • Covert networks, like criminal organizations, exhibit unique structures (core-periphery, assortative/disassortative) that are difficult to detect.
  • Existing community detection algorithms struggle with noisy, multi-patterned networks.

Purpose of the Study:

  • Develop a novel class of extended stochastic block models (esbm) to reliably infer group structures in complex networks.
  • Incorporate node attributes and provide robust estimation and uncertainty quantification for network analysis.
  • Characterize node partition processes in realistic scenarios, including criminal networks.

Main Methods:

  • Introduced extended stochastic block models (esbm) with Gibbs-type priors on the partition process.
  • Utilized the Gnedin process as a prior allowing for finite, random, and reinforced group structures.
  • Developed a collapsed Gibbs sampler for estimation, prediction, uncertainty quantification, and model selection.

Main Results:

  • Demonstrated the effectiveness of esbm in realistic simulations.
  • Successfully applied esbm to an Italian mafia network, revealing complex block structures.
  • Identified key network architectures previously hidden from state-of-the-art methods.

Conclusions:

  • Extended stochastic block models (esbm) offer a powerful and flexible framework for analyzing complex network structures.
  • The proposed methods provide reliable group inference, even in the presence of noise and mixed patterns.
  • This approach enhances our understanding of organizational structures in covert networks.