Nodular Sclerosing Hodgkin Lymphoma With Paraneoplastic Cerebellar Degeneration

There are a variety of paraneoplastic syndromes associated with Hodgkin lymphoma including paraneoplastic cerebellar degeneration (PCD), which is associated with unique autoantibodies, such as anti-Tr antibody. Most of these autoimmune phenomena involve older adult patients with abrupt, acute presentations.

We report an atypical case of a young adult female patient with slow progressive onset of PCD symptoms with subsequent detection and treatment of Hodgkin lymphoma.

Early detection of PCD is critical, as treatment of the underlying malignancy decreases overall morbidity and disability.