Related Experiment Video

Updated: Aug 20, 2025

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber
08:47

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber

Published on: March 3, 2023

2.5K

Duration of clinical symptoms in children with acute respiratory infection

Niko Paalanne1,2, Minna Honkila1,2, Suvi Mattila1,2

  • 1Department of Pediatrics and Adolescent Medicine, Oulu University Hospital, Oulu, Finland.

Acta Paediatrica (Oslo, Norway : 1992)
|November 25, 2022
PubMed

Insights

Persistent respiratory symptoms are common in children after viral infections. Co-detection of viral and bacterial pathogens may prolong illness duration, particularly fever.

Area of Science:

  • Pediatric Infectious Diseases
  • Respiratory Virology
  • Microbiome Research

Background:

  • Respiratory viral infections are a leading cause of acute illness in children.
  • Understanding the duration of symptoms and factors influencing prolonged illness is crucial for clinical management.
  • Co-infections with bacterial pathogens may impact clinical outcomes.

Purpose of the Study:

  • To determine the duration of clinical symptoms associated with various respiratory viruses in children.
  • To investigate the impact of co-detection of respiratory viral and bacterial pathogens on symptom duration.

Main Methods:

  • Prospective cohort study of 737 acutely ill children.
  • Multiplex PCR analysis of nasal swabs for 16 viral and 7 bacterial pathogens.
  • Parental questionnaires recorded symptoms at presentation and 14 days post-illness.

Main Results:

  • 32% of children with coronavirus, 31% with human metapneumovirus, and 25% with rhinovirus reported persistent symptoms at 14 days.
  • 3-4% of children experienced symptoms lasting over 4 weeks.
  • Viral and bacterial co-detection was associated with a longer duration of fever (3.3 days) compared to viral detection alone (1.6 days).

Conclusions:

  • Symptom persistence beyond 2-4 weeks is common in pediatric respiratory viral infections.
  • Co-detection of viral and bacterial pathogens may prolong illness duration in children.
Abstract

Keywords:
co-detectionpneumococcusrespiratory pathogen

More Related Videos

Long Term Chronic Pseudomonas aeruginosa Airway Infection in Mice15:43

Long Term Chronic Pseudomonas aeruginosa Airway Infection in Mice

Published on: March 17, 2014

22.9K
An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection09:01

An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection

Published on: December 10, 2013

8.0K

Related Concept Videos

Pulmonary Cycle: Exhalation01:17

Pulmonary Cycle: Exhalation

In terms of human respiration, the act of expelling air, known as exhalation (or expiration), operates on the principle of pressure gradients. During expiration, the pressure within the lungs exceeds that of the surrounding atmosphere. Under normal conditions, quiet breathing involves passive exhalation and is free of muscular contractions. This is because the exhalation process is driven by the natural elastic recoil of the lungs and chest wall, both of which have an inherent tendency to...
1.7K
Acute Respiratory Failure-IV01:23

Acute Respiratory Failure-IV

Respiratory failure can manifest suddenly or gradually, characterized by a rapid decline in PaO2 and a rapid rise in PaCO2. This situation indicates a severe respiratory problem that may quickly become a life-threatening emergency. One of the early signs of hypoxemic Acute Respiratory Failure (ARF) is a change in mental status due to the brain's sensitivity to oxygen levels and changes in acid-base balance. Symptoms such as restlessness, confusion, and agitation suggest inadequate oxygen...
189
Stages of Infection01:26

Stages of Infection

Stages of infection describe what happens to a susceptible host once a pathogen invades the human body. The stages of infection are incubation, prodromal, illness, stage of decline, and convalescence. The incubation stage is the period from exposure to a pathogen until symptoms start. The infected person is unaware of impending illness as the pathogens grow and multiply within the body. The duration may vary depending on the type of infection. The incubation period of measles averages ten to...
58.2K
Acute Pharyngitis01:30

Acute Pharyngitis

Introduction
Acute pharyngitis is the inflammation of the back of the throat (pharynx), commonly resulting in a sore throat. It is a frequently encountered condition that prompts individuals to seek medical advice.
Classification
Acute pharyngitis can be categorized based on its underlying cause:
1.3K
Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
2.6K
Pneumonia II: Pathophysiology01:29

Pneumonia II: Pathophysiology

The pathophysiology of pneumonia involves the following steps:
423