The estrogen receptor polymorphisms and controlled ovulation hyperstimulation outcomes: a meta-analysis.

Area of Science:

• Reproductive Endocrinology
• Human Genetics
• Infertility Research

Background:

• Estrogen receptor (ER) polymorphisms have been investigated for their association with controlled ovulation hyperstimulation (COH) outcomes, but previous findings remain inconclusive.
• A comprehensive meta-analysis is needed to clarify the relationship between various ER polymorphisms and COH success rates.

Approach:

• A systematic meta-analysis was conducted by searching PubMed, Embase, and CNKI databases up to November 2021.
• Thirteen eligible studies were included, analyzing correlations between ER polymorphisms and COH outcomes using odds ratios (OR) and weighted mean differences (WMD) with 95% confidence intervals (CIs).

Key Points:

• PvuII polymorphism significantly correlated with IVF pregnancy outcomes across multiple models, exhibiting substantial heterogeneity.
• XbaI and (TA)n polymorphisms were significantly associated with IVF risk in specific models without heterogeneity.
• Alul polymorphism showed a significant association with poor ovarian response (POR) risk in the recessive model, with no heterogeneity.

Conclusions:

• PvuII polymorphism may serve as a predictive marker for IVF-ET pregnancy rates.
• XbaI and (TA)n polymorphisms are potentially linked to infertility.
• Alul polymorphism may predict poor ovarian response to COH, warranting further investigation.