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Related Concept Videos

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Related Experiment Video

Updated: Aug 20, 2025

Engineering Three-dimensional Epithelial Tissues Embedded within Extracellular Matrix
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Rete ridges: Morphogenesis, function, regulation, and reconstruction.

Zhizhong Shen1, Lei Sun2, Zixian Liu2

  • 1Shanxi Key Laboratory of Micro Nano Sensors & Artificial Intelligence Perception, College of Information and Computer, Taiyuan University of Technology, Taiyuan 030024, China.

Acta Biomaterialia
|November 25, 2022
PubMed
Summary

Rete ridges (RRs), crucial skin microstructures, are often missing in artificial skin grafts. This review details RR structure, function, and novel reconstruction strategies for improved tissue-engineered skin (TES) repair.

Keywords:
Artificial skin graftsReconstructionRete ridgesTissue-engineered skin

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Area of Science:

  • Dermatology
  • Tissue Engineering
  • Regenerative Medicine

Background:

  • Rete ridges (RRs) are vital skin microstructures enhancing mechanical properties and homeostasis.
  • Current tissue-engineered skin (TES) often lacks functional RRs, potentially limiting healing efficacy.
  • Reconstruction of RRs in TES remains an under-addressed area in scientific literature.

Purpose of the Study:

  • To review current knowledge on rete ridge (RR) structure, function, and development.
  • To explore and collate strategies for reconstructing RRs in tissue-engineered skin (TES).
  • To discuss limitations of existing RR reconstruction methods and their clinical translation.

Main Methods:

  • Comprehensive literature review of research on rete ridges (RRs).
  • Analysis of studies focusing on tissue-engineered skin (TES) development and repair.
  • Synthesis of information on RR morphogenesis and influencing factors.

Main Results:

  • RRs significantly contribute to skin's mechanical integrity and homeostasis.
  • Various reconstruction strategies for RRs in TES are emerging.
  • Existing methods for RR reconstruction in TES have limitations impacting clinical application.

Conclusions:

  • Restoring rete ridges (RRs) is critical for advancing tissue-engineered skin (TES) efficacy.
  • Further research into robust RR reconstruction methods is needed for clinical translation.
  • This review provides a foundation for developing TES with functional RR structures.