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Endometrial cancer: Part I. Basic concept
Peng-Hui Wang1, Szu-Ting Yang2, Chia-Hao Liu2
1Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei, Taiwan; Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Female Cancer Foundation, Taipei, Taiwan; Department of Medical Research, China Medical University Hospital, Taichung, Taiwan.
Taiwanese Journal of Obstetrics & Gynecology
|November 25, 2022
Summary
Endometrial cancer (EC) is a growing concern, especially high-grade types that risk recurrence. Personalized therapies using molecular insights aim to improve treatment efficacy while reducing toxicity for better outcomes.
Area of Science:
- Gynecologic Oncology
- Reproductive Medicine
- Cancer Biology
Background:
- Endometrial cancer (EC) is a prevalent malignancy in women, particularly in high- and middle-income nations.
- While generally having a favorable prognosis, high-grade EC poses significant challenges due to recurrence and advanced-stage disease.
- Current treatment involves surgery and adjuvant therapies (radiotherapy, chemotherapy, targeted therapy) based on risk stratification.
Purpose of the Study:
- To provide a comprehensive overview of endometrial cancer (cancer of the uterine corpus).
- To discuss the evolution towards patient-tailored therapeutic strategies.
- To highlight the role of modern molecular technology in optimizing treatment.
Main Methods:
- Review of existing literature on endometrial cancer.
- Analysis of clinicopathological prognostic factors.
- Exploration of advancements in molecular diagnostics and targeted therapies.
Main Results:
- High-grade EC presents a therapeutic challenge with a tendency for recurrence and metastasis.
- Standard treatment relies on surgical staging and adjuvant therapies guided by prognostic factors.
- Molecular technologies are enabling a shift towards personalized treatment approaches.
Conclusions:
- Personalized therapy based on molecular profiling offers a promising strategy for endometrial cancer.
- This tailored approach aims to balance treatment effectiveness with reduced toxicity.
- Optimizing treatment strategies can lead to improved patient benefits and outcomes.
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