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Endometrial cancer: Part I. Basic concept.

Peng-Hui Wang1, Szu-Ting Yang2, Chia-Hao Liu2

  • 1Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei, Taiwan; Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Female Cancer Foundation, Taipei, Taiwan; Department of Medical Research, China Medical University Hospital, Taichung, Taiwan.

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|November 25, 2022
PubMed
Summary

Endometrial cancer (EC) is a growing concern, especially high-grade types that risk recurrence. Personalized therapies using molecular insights aim to improve treatment efficacy while reducing toxicity for better outcomes.

Keywords:
Clinicopathologic factorsEndometrial cancerPatient-tailored therapyPrecise medicine

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Area of Science:

  • Gynecologic Oncology
  • Reproductive Medicine
  • Cancer Biology

Background:

  • Endometrial cancer (EC) is a prevalent malignancy in women, particularly in high- and middle-income nations.
  • While generally having a favorable prognosis, high-grade EC poses significant challenges due to recurrence and advanced-stage disease.
  • Current treatment involves surgery and adjuvant therapies (radiotherapy, chemotherapy, targeted therapy) based on risk stratification.

Purpose of the Study:

  • To provide a comprehensive overview of endometrial cancer (cancer of the uterine corpus).
  • To discuss the evolution towards patient-tailored therapeutic strategies.
  • To highlight the role of modern molecular technology in optimizing treatment.

Main Methods:

  • Review of existing literature on endometrial cancer.
  • Analysis of clinicopathological prognostic factors.
  • Exploration of advancements in molecular diagnostics and targeted therapies.

Main Results:

  • High-grade EC presents a therapeutic challenge with a tendency for recurrence and metastasis.
  • Standard treatment relies on surgical staging and adjuvant therapies guided by prognostic factors.
  • Molecular technologies are enabling a shift towards personalized treatment approaches.

Conclusions:

  • Personalized therapy based on molecular profiling offers a promising strategy for endometrial cancer.
  • This tailored approach aims to balance treatment effectiveness with reduced toxicity.
  • Optimizing treatment strategies can lead to improved patient benefits and outcomes.