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Articles linked to this work by shared authors, journal, and citation graph.

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Correction: Chueh et al. Therapeutic Effect of Platelet-Rich Plasma Improves Bladder Overactivity in the Pathogenesis of Ketamine-Induced Ulcerative Cystitis in a Rat Model. <i>Int. J. Mol. Sci.</i> 2022, <i>23</i>, 5771.

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Factors Affecting Oncological Outcomes in Upper Tract Urothelial Carcinoma Patients with Chronic Kidney Disease and End-Stage Renal Disease.

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Screening for Clinically Significant Nephrolithiasis Based on Simple Health Checkup Clinical and Urine Parameters in General Populations: Multicenter Machine Learning Study.

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Correction: Lin et al. Effects of Nitric Oxide on Bladder Detrusor Overactivity Through the NRF2 and HIF-1α Pathways: A Rat Model Induced by Metabolic Syndrome and Ovarian Hormone Deficiency. <i>Int. J. Mol. Sci.</i> 2024, <i>25</i>, 11103.

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Pre-Existing Nocturia Status Predicts Bladder Symptom Exacerbation Following COVID-19 Vaccination in Women.

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Correction: Lu et al. Autophagy Alters Bladder Angiogenesis and Improves Bladder Hyperactivity in the Pathogenesis of Ketamine-Induced Cystitis in a Rat Model. <i>Biology</i> 2021, <i>10</i>, 488.

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Related Experiment Video

Updated: Aug 20, 2025

Detrusor Underactivity Model in Rats by Conus Medullaris Transection
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Detrusor Underactivity in Men with Bladder Outlet Obstruction.

Hsiang-Ying Lee1,2,3,4, Chien-Sheng Wang1, Yung-Shun Juan1,2

  • 1Department of Urology, Kaohsiung Medical University Hospital, Kaohsiung 800-852, Taiwan.

Biomedicines
|November 26, 2022
PubMed
Summary

Detrusor underactivity (DU) with bladder outlet obstruction (BOO) in men is poorly understood. Releasing obstruction is key for treatment, but effective medications to restore bladder function are lacking, necessitating further research.

Keywords:
bladder outlet obstructiondetrusor underactivitymen

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Area of Science:

  • Urology
  • Men's Health

Background:

  • Detrusor underactivity (DU) and bladder outlet obstruction (BOO) are common causes of lower urinary tract symptoms (LUTS) in men.
  • These conditions often coexist and significantly impact quality of life.

Purpose of the Study:

  • To focus on the pathophysiology, evaluation, and treatment of DU specifically in male patients with concurrent BOO.
  • To review predictors for successful surgical management of BOO in the context of DU.

Main Methods:

  • Literature search of original articles on DU with BOO from PubMed and EMBASE databases.
  • Selection of 38 relevant articles for review.

Main Results:

  • DU associated with BOO involves complex pathophysiological mechanisms.
  • Urodynamic study (UDS) is precise for diagnosis, though non-invasive methods are emerging.
  • Releasing outlet obstruction is the primary treatment strategy; medications to enhance bladder contractility have limited efficacy.

Conclusions:

  • DU with BOO remains poorly understood and under-researched, particularly regarding etiology and pathophysiology.
  • There is a lack of effective and safe medications to restore bladder contractility.
  • Further research is crucial to elucidate the unknown aspects of DU in the setting of BOO.