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Cytomegalovirus Disease01:27

Cytomegalovirus Disease

Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...

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The Role of Cluster C19MC in Pre-Eclampsia Development.

Ilona Jaszczuk1, Izabela Winkler2, Dorota Koczkodaj1

  • 1Department of Cancer Genetics with Cytogenetic Laboratory, Medical University of Lublin, Radziwillowska Street 11, 20-080 Lublin, Poland.

International Journal of Molecular Sciences
|November 26, 2022
PubMed
Summary

Pre-eclampsia, a pregnancy complication, may be linked to chromosome 19 microRNA cluster (C19MC) deregulation. These C19MC microRNAs show altered expression, suggesting their potential as early biomarkers for pre-eclampsia.

Keywords:
C19MCmicroRNAspre-eclampsiapregnancy

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Area of Science:

  • Genetics and Epigenetics
  • Reproductive Medicine
  • Molecular Biology

Background:

  • Pre-eclampsia affects 2-10% of pregnancies, posing risks to mother and fetus.
  • MicroRNAs (miRNAs) are key gene regulators, with C19MC miRNAs implicated in placental development.
  • Dysregulation of C19MC miRNAs is associated with placental abnormalities contributing to pre-eclampsia.

Purpose of the Study:

  • To review and summarize current research on the role of C19MC miRNAs in pre-eclampsia development.
  • To explore the potential of C19MC miRNAs as diagnostic biomarkers for pre-eclampsia.

Main Methods:

  • Systematic literature review of articles from PubMed Medline (2009-2022).
  • Analysis of studies investigating C19MC miRNA expression in pre-eclampsia.
  • Examination of miRNA levels in placental tissue, serum, and plasma.

Main Results:

  • Most C19MC miRNAs exhibit significantly increased expression in placental tissue of pre-eclamptic women.
  • Elevated circulating levels of C19MC miRNAs are observed in serum and plasma during pregnancy.
  • miR-525-5p shows decreased plasma expression in the first trimester and placental expression in the third trimester.

Conclusions:

  • C19MC miRNAs are significantly altered in pre-eclampsia, indicating their involvement in the condition.
  • C19MC miRNAs show promise as early, pre-symptomatic biomarkers for identifying women at risk of pre-eclampsia.
  • Further research into C19MC miRNAs could lead to improved diagnostic strategies and management of pre-eclampsia.