Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Whole Body Regeneration01:33

Whole Body Regeneration

3.4K
Regeneration is the process of restoring injured or lost tissues, organs, or body parts. While simpler organisms generally show greater ability to regenerate their whole body, few complex animals show similarly exceptional regeneration. For example, planarian flatworms have a unique regenerative potential making them a popular study organism among biologists to understand the mechanisms of whole body regeneration. Other organisms, such as hydra, also show extreme regeneration potential;...
3.4K
Renewal of Skin Epidermal Stem Cells01:12

Renewal of Skin Epidermal Stem Cells

2.6K
The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
2.6K
Renewal of Intestinal Stem Cells01:23

Renewal of Intestinal Stem Cells

2.7K
The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the...
2.7K
Tissue Renewal without Stem Cells01:23

Tissue Renewal without Stem Cells

1.8K
After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...
1.8K
Overview of Regeneration and Repair01:19

Overview of Regeneration and Repair

4.2K
Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
Regeneration
All animals have varying degrees of...
4.2K
Replicative Cell Senescence02:15

Replicative Cell Senescence

3.7K
Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds...
3.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Utilize Metabolomics Molecular Networking to Guide the Discovery of Chemical Entities from <i>Cordyceps militaris</i> Against Blue Light Hazards.

Journal of natural products·2026
Same author

Correction: Chang et al. Inhibition of CCAR1, a Coactivator of β-Catenin, Suppresses the Proliferation and Migration of Gastric Cancer Cells. <i>Int. J. Mol. Sci.</i> 2017, <i>18</i>, 460.

International journal of molecular sciences·2026
Same author

Alleviation of Helicobacter pylori-Induced Pathogenicity and Gastric Inflammation by Majonoside-R2- and Ginsenoside Rg1-Rich Fractions From Panax vietnamensis Ha Et Grushv.: A Metabolomics-Guided Investigation.

Molecular nutrition & food research·2026
Same author

PKF118-310 as a Potential Small Molecule Inhibitor Targeting the Wnt/β-Catenin Pathway for Gastric Cancer Therapy.

Anticancer research·2026
Same author

Dietary restriction mitigates cognitive impairments in a mouse model of SCA19/22.

Mechanisms of ageing and development·2026
Same author

Cancer suppresses mitochondrial chaperone activity in macrophages to drive immune evasion.

Nature immunology·2025

Related Experiment Video

Updated: Aug 19, 2025

Voltage Biasing, Cyclic Voltammetry, & Electrical Impedance Spectroscopy for Neural Interfaces
07:51

Voltage Biasing, Cyclic Voltammetry, & Electrical Impedance Spectroscopy for Neural Interfaces

Published on: February 24, 2012

24.8K

Rejuvenation: Turning Back Time by Enhancing CISD2.

Chi-Hsiao Yeh1,2, Zhao-Qing Shen3, Ching-Cheng Lin3

  • 1Department of Thoracic and Cardiovascular Surgery, Chang Gung Memorial Hospital, Linkou 333, Taiwan.

International Journal of Molecular Sciences
|November 26, 2022
PubMed
Summary

CDGSH iron-sulfur domain 2 (CISD2) is a pro-longevity gene that plays a key role in aging and age-associated diseases. Pharmaceutical activation of CISD2, like with hesperetin, can slow aging and promote longevity.

Keywords:
CISD2agingcalcium homeostasishesperetinlongevitymitochondriarejuvenation

More Related Videos

Reactivation of Demembranated Cell Models in Chlamydomonas reinhardtii
03:37

Reactivation of Demembranated Cell Models in Chlamydomonas reinhardtii

Published on: May 6, 2022

2.2K
An Engineered Split-TET2 Enzyme for Chemical-inducible DNA Hydroxymethylation and Epigenetic Remodeling
08:34

An Engineered Split-TET2 Enzyme for Chemical-inducible DNA Hydroxymethylation and Epigenetic Remodeling

Published on: December 18, 2017

6.7K

Related Experiment Videos

Last Updated: Aug 19, 2025

Voltage Biasing, Cyclic Voltammetry, & Electrical Impedance Spectroscopy for Neural Interfaces
07:51

Voltage Biasing, Cyclic Voltammetry, & Electrical Impedance Spectroscopy for Neural Interfaces

Published on: February 24, 2012

24.8K
Reactivation of Demembranated Cell Models in Chlamydomonas reinhardtii
03:37

Reactivation of Demembranated Cell Models in Chlamydomonas reinhardtii

Published on: May 6, 2022

2.2K
An Engineered Split-TET2 Enzyme for Chemical-inducible DNA Hydroxymethylation and Epigenetic Remodeling
08:34

An Engineered Split-TET2 Enzyme for Chemical-inducible DNA Hydroxymethylation and Epigenetic Remodeling

Published on: December 18, 2017

6.7K

Area of Science:

  • Geriatric medicine
  • Molecular biology
  • Genetics

Background:

  • The global population of individuals aged 65 and older is rapidly increasing, making age-associated diseases a significant concern.
  • CDGSH iron-sulfur domain 2 (CISD2) is crucial for maintaining cellular functions, including mitochondrial health, endoplasmic reticulum integrity, and redox balance, impacting lifespan and healthspan.

Purpose of the Study:

  • To review the current literature on CISD2's role in aging and age-associated diseases.
  • To highlight CISD2 as a potential therapeutic target for promoting longevity and healthspan.

Main Methods:

  • Review of existing publications on CISD2 function and genetic studies (loss-of-function and gain-of-function).
  • Analysis of studies investigating pharmaceutical activation of CISD2 in aged mice.
  • Transcriptomic analysis of skeletal muscle to understand hesperetin's mechanism of action.

Main Results:

  • CISD2 is a pro-longevity gene essential for lifespan control, as evidenced by genetic studies.
  • Increased CISD2 levels alleviate age-associated disorders like Alzheimer's disease and non-alcoholic fatty liver disease.
  • Pharmaceutical activation of CISD2, using hesperetin, demonstrated a slowing of aging and promotion of longevity in aged mice.
  • Hesperetin's anti-aging effects are largely CISD2-dependent, impacting lipid metabolism, protein homeostasis, and amino acid metabolism in skeletal muscle.

Conclusions:

  • CISD2 is a critical regulator of aging and a promising target for therapeutic interventions.
  • Pharmacological strategies aimed at activating CISD2 hold potential for developing treatments to extend healthy lifespan and combat age-related diseases.