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Serum Biomarkers of Renal Fibrosis: A Systematic Review

Alice Barinotti1,2, Massimo Radin1,2, Irene Cecchi1,2

  • 1University Center of Excellence on Nephrologic, Rheumatologic and Rare Diseases (ERK-Net, ERN-Reconnect and RITA-ERN Member) with Nephrology and Dialysis Unit and Center of Immuno-Rheumatology and Rare Diseases (CMID), Coordinating Center of the Interregional Network for Rare Diseases of Piedmont and Aosta Valley, San Giovanni Bosco Hub Hospital, 10154 Turin, Italy.

International Journal of Molecular Sciences
|November 26, 2022
PubMed

Insights

Identifying non-invasive biomarkers for renal fibrosis in chronic kidney disease (CKD) is crucial. Current evidence is scattered, suggesting a need for multi-faceted approaches to improve diagnosis and management.

Area of Science:

  • Nephrology
  • Biomarker Discovery
  • Pathophysiology

Background:

  • Chronic kidney disease (CKD) is a global health concern with rising prevalence.
  • Renal fibrosis, an irreversible process, is the primary driver of CKD progression and dysfunction.
  • Current diagnostic methods like kidney biopsy are invasive and have limitations.

Approach:

  • Systematic review of serological biomarkers for renal fibrosis in CKD patients.
  • Analysis focused on evidence published within the last five years.
  • Evaluation of the scattered nature of current research findings.

Key Points:

  • Several promising serological biomarkers for renal fibrosis have been identified.
  • The existing evidence for these biomarkers is highly fragmented and requires further validation.
  • No single biomarker appears sufficient to capture the complexity of renal fibrosis.

Conclusions:

  • Novel non-invasive biomarkers for renal fibrosis are urgently needed in CKD management.
  • A combination of biomarkers targeting different aspects of fibrosis may offer a more comprehensive diagnostic and prognostic tool.
  • Integrated biomarker strategies could significantly enhance prevention, diagnosis, and management of CKD.

Keywords:
biomarkerschronic kidney diseaserenal fibrosis

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