Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Disorders of the Male Reproductive System01:20

Disorders of the Male Reproductive System

522
Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
522
Tumor Progression02:07

Tumor Progression

6.4K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.4K
The Tumor Microenvironment02:17

The Tumor Microenvironment

6.7K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.7K
Cancer02:18

Cancer

49.2K
Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
49.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of Cerebral Microbleeds on Tau-Associated Cognitive and Structural Decline.

Neurology·2025
Same author

Emerging Concepts of Targeted Protein Degrader Technologies via Lysosomal Pathways.

International journal of molecular sciences·2025
Same author

PET tracer development for imaging α-synucleinopathies.

Archives of pharmacal research·2025
Same author

Neuroprotective Efficacy of <i>Astragalus mongholicus</i> in Ischemic Stroke: Antioxidant and Anti-Inflammatory Mechanisms.

Cells·2025
Same author

CRISPR/Cas9 Technology Providing the Therapeutic Landscape of Metastatic Prostate Cancer.

Pharmaceuticals (Basel, Switzerland)·2025
Same author

Synthesis, biological evaluation, and <i>in silico</i> studies of lantadene-derived pentacyclic triterpenoids as anticancer agents targeting IKK-β.

Journal of biomolecular structure & dynamics·2024

Related Experiment Video

Updated: Aug 19, 2025

Author Spotlight: Advancing Prostate Cancer Research Through Improved Tissue Sampling and Biobanking
07:34

Author Spotlight: Advancing Prostate Cancer Research Through Improved Tissue Sampling and Biobanking

Published on: November 17, 2023

735

Complexities of Prostate Cancer.

Sobia Wasim1, Sang-Yoon Lee1, Jaehong Kim2

  • 1Department of Neuroscience, College of Medicine, Gachon University, Incheon 21936, Republic of Korea.

International Journal of Molecular Sciences
|November 26, 2022
PubMed
Summary

Recent advances in deep sequencing and imaging have improved prostate cancer (PCa) research and patient care. This review covers progress in PCa biology, diagnostics, and therapeutics, highlighting areas for improvement.

Keywords:
AR signalingPSAmutationprostate cancerresistance

More Related Videos

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
07:25

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

13.2K
Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer
13:19

Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer

Published on: November 2, 2013

16.7K

Related Experiment Videos

Last Updated: Aug 19, 2025

Author Spotlight: Advancing Prostate Cancer Research Through Improved Tissue Sampling and Biobanking
07:34

Author Spotlight: Advancing Prostate Cancer Research Through Improved Tissue Sampling and Biobanking

Published on: November 17, 2023

735
A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
07:25

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

13.2K
Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer
13:19

Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer

Published on: November 2, 2013

16.7K

Area of Science:

  • Oncology
  • Genomics
  • Molecular Biology

Background:

  • Prostate cancer (PCa) exhibits variable clinical progression.
  • Recent advancements in deep sequencing offer novel cistromic and transcriptomic insights into PCa.
  • Improved understanding of PCa biology is crucial for enhanced patient outcomes.

Purpose of the Study:

  • To review current progress in understanding prostate cancer biology.
  • To discuss recent advances in diagnostic and therapeutic strategies for prostate cancer.
  • To identify areas for improvement in theragnostic schemes for prostate cancer.

Main Methods:

  • Literature review of recent studies on prostate cancer.
  • Analysis of advancements in deep sequencing technologies (cistromics, transcriptomics).
  • Evaluation of progress in bedside and molecular imaging techniques.

Main Results:

  • Deep sequencing has significantly expanded knowledge of prostate cancer at the molecular level.
  • Molecular imaging and bedside techniques have enhanced the understanding of prostate cancer biology.
  • Current diagnostic modalities and therapeutic strategies require further improvement, particularly for non-androgen receptor (AR) signaling.

Conclusions:

  • Continued research into prostate cancer biology is essential.
  • Advancements in diagnostics and therapeutics offer new hope for prostate cancer patients.
  • Improving theragnostic schemes, including non-AR targeted therapies, is critical for future treatment strategies.