Related Experiment Video

Updated: Aug 19, 2025

The Use of Reverse Phase Protein Arrays RPPA to Explore Protein Expression Variation within Individual Renal Cell Cancers
12:22

The Use of Reverse Phase Protein Arrays RPPA to Explore Protein Expression Variation within Individual Renal Cell Cancers

Published on: January 22, 2013

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Renal Cell Carcinoma as a Metabolic Disease: An Update on Main Pathways, Potential Biomarkers, and Therapeutic

Nicola Antonio di Meo1, Francesco Lasorsa1, Monica Rutigliano1

  • 1Urology, Andrology and Kidney Transplantation Unit, Department of Emergency and Organ Transplantation, University of Bari "Aldo Moro", 70124 Bari, Italy.

International Journal of Molecular Sciences
|November 26, 2022
PubMed

Insights

Clear cell renal cell carcinoma (ccRCC) is a metabolic disease. Understanding ccRCC metabolic pathways offers new strategies for patient-tailored therapies and predicting cancer behavior.

Area of Science:

  • Oncology
  • Metabolomics
  • Genetics

Background:

  • Clear cell renal cell carcinoma (ccRCC) is the most common kidney cancer.
  • Recent advances link ccRCC development to genetic and metabolic alterations.
  • Integrated omics approaches reveal ccRCC as a metabolic disease.

Purpose of the Study:

  • To review current research on ccRCC metabolic pathways.
  • To explore potential therapeutic applications targeting metabolism.
  • To analyze the clinical implications of pharmacometabolomics in ccRCC.

Main Methods:

  • Review of transcriptomics, metabolomics, and lipidomics studies.
  • Analysis of metabolic profiling data in ccRCC.
  • Examination of pharmacometabolomic intervention strategies.

Main Results:

  • Metabolic profiling aids in understanding ccRCC aggressiveness, prognosis, and treatment response.
  • ccRCC exhibits distinct metabolic alterations driving its development.
  • Pharmacometabolomics offers novel patient-tailored therapeutic strategies.

Conclusions:

  • Metabolic insights are crucial for understanding ccRCC.
  • Targeting ccRCC metabolic pathways presents therapeutic opportunities.
  • Pharmacometabolomics enables personalized treatment strategies for ccRCC patients.
Keywords:
Warburg effectbiomarkermetabolismmetabolomicsrenal cell carcinoma

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