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Updated: Aug 19, 2025
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Isolation and Quantification of Epstein-Barr Virus from the P3HR1 Cell Line
Published on: September 28, 2022
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Epstein-Barr Virus (EBV) Epithelial Associated Malignancies: Exploring Pathologies and Current Treatments
Oren Shechter1, Daniel G Sausen1, Elisa S Gallo2
1Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, VA 23501, USA.
International Journal of Molecular Sciences
|November 26, 2022
Summary
Epstein-Barr virus (EBV), a common herpesvirus, is linked to epithelial cancers like nasopharyngeal, gastric, and breast cancer. This review details EBV-associated malignancies and recommended treatments.
Area of Science:
- Oncology
- Virology
- Infectious Diseases
Background:
- Epstein-Barr virus (EBV) is a ubiquitous herpesvirus, infecting 90-95% of the global population.
- EBV is recognized as an oncogenic virus with established links to several epithelial cancers.
- Emerging research indicates a potential association between EBV and breast cancer, alongside other rarer malignancies.
Purpose of the Study:
- To comprehensively review epithelial malignancies associated with Epstein-Barr virus.
- To delineate the strength of evidence linking EBV to various cancers.
- To identify and recommend optimal treatments and therapies for EBV-associated cancers.
Main Methods:
- Literature review of scientific publications.
- Analysis of epidemiological data on EBV prevalence and cancer incidence.
- Synthesis of clinical evidence regarding EBV and malignancy.
- Review of current therapeutic strategies for EBV-related cancers.
Main Results:
- EBV is strongly associated with nasopharyngeal and gastric cancers.
- Evidence suggests a connection between EBV and breast cancer.
- Other epithelial malignancies show weaker associations with EBV.
- Specific treatment protocols are recommended based on cancer type and EBV association.
Conclusions:
- Epstein-Barr virus plays a significant role in the pathogenesis of various epithelial cancers.
- Understanding these associations is crucial for diagnosis and treatment.
- Further research is warranted to explore EBV's role in rarer cancers and to refine therapeutic approaches.
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