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Related Experiment Video

Updated: Aug 19, 2025

Ablation of Ischemic Ventricular Tachycardia Using a Multipolar Catheter and 3-dimensional Mapping System for High-density Electro-anatomical Reconstruction
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A Bionic Testbed for Cardiac Ablation Tools.

Wei-Han Lin1,2, Zhijie Zhu3, Vasanth Ravikumar4

  • 1Department of Biomedical Engineering, University of Minnesota-Twin Cities, Minneapolis, MN 55455, USA.

International Journal of Molecular Sciences
|November 26, 2022
PubMed
Summary
This summary is machine-generated.

Researchers developed centimeter-scale bionic human cardiac tissue for testing medical devices. This engineered tissue, coupled with a soft pressure sensor, reveals how ablation affects heart cells and could predict arrhythmia recurrence.

Keywords:
3D printingbioprintingcryoablationinduced pluripotent stem cellsmedical device testbedssoft sensorstissue engineering

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Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Cardiovascular Research

Background:

  • Bionic-engineered tissues offer ex vivo testing for cardiovascular devices.
  • Existing engineered tissues are too small for clinical devices.
  • Compliant electronics for tissue monitoring are advancing.

Purpose of the Study:

  • To create centimeter-scale bionic human cardiac tissue for evaluating cardiac ablation tools.
  • To couple engineered cardiac tissue with a soft-pressure sensor for device testing.
  • To investigate human cardiomyocyte response to ablation and pressure variations.

Main Methods:

  • 3D bioprinting of human pluripotent stem cells in a specialized bioink for cardiac tissue generation.
  • Development of a hydrogel-based soft-pressure sensor using electrical impedance tomography.
  • Application of a cryoablation tip catheter to the bionic tissue model with controlled pressure.

Main Results:

  • Generated centimeter-scale human cardiac tissue with contiguous electromechanical function.
  • Demonstrated real-time spatiotemporal pressure mapping using the soft-pressure sensor.
  • Found a correlation between cell response to ablation and applied pressure, observing cardiomyocyte survival, morphological changes, and disrupted connectivity.

Conclusions:

  • This study presents the first functional characterization of human cardiomyocytes post-ablation in a bionic-engineered testbed.
  • The findings suggest mechanisms for arrhythmia redevelopment after ablation.
  • Bionic-engineered tissues serve as valuable indicators of tissue health and provide insights into cellular responses to interventions.