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High-speed Video Microscopy Analysis for First-line Diagnosis of Primary Ciliary Dyskinesia
Published on: January 19, 2022
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Reversible Bronchial Obstruction in Primary Ciliary Dyskinesia
Hagit Levine1,2, Ophir Bar-On1,2, Vered Nir3
1Pulmonary Institute, Schneider Children's Medical Center, Petah-Tikva 49100, Israel.
Journal of Clinical Medicine
|November 26, 2022
Summary
More than half of primary ciliary dyskinesia (PCD) patients show reversible airway obstruction. Bronchodilator use is common in PCD, but their effectiveness requires further study.
Area of Science:
- Pulmonary Medicine
- Rare Diseases
- Respiratory Physiology
Background:
- Inhaled bronchodilators are common for primary ciliary dyskinesia (PCD) patients.
- Effectiveness and prevalence of bronchodilator use in PCD are largely unknown.
- Limited studies exist on bronchodilator use in PCD management.
Purpose of the Study:
- To determine the prevalence of reversible airway obstruction in PCD patients.
- To investigate the association between bronchodilator response and atopy markers.
- To assess the current use of bronchodilators and inhaled corticosteroids in PCD.
Main Methods:
- Retrospective analysis of spirometry data from two centers.
- Examined pre- and post-bronchodilator spirometry results in PCD patients.
- Correlated bronchodilator response with asthma and atopy markers.
Main Results:
- 40% of patients (46/115) completed pre- and post-bronchodilator spirometry.
- 56.5% of these patients (26/46) exhibited reversible airway obstruction.
- No association found between reversibility and family history of asthma, blood eosinophils, IgE, or atopy symptoms.
- 63% of patients (29/46) regularly used bronchodilators and inhaled corticosteroids.
Conclusions:
- Over half of PCD patients have reversible airway obstruction.
- Reversibility is not linked to personal or familial atopy markers.
- Bronchodilators and corticosteroids are frequently used in PCD treatment.
- Evaluating bronchodilator response in PCD is recommended; effectiveness needs further research.
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