Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Blood Pressure Imbalances and Circulatory Shock01:24

Blood Pressure Imbalances and Circulatory Shock

953
Disorders affecting blood volume, vascular tone, or vascular function can disrupt vascular homeostasis, including conditions like hypertension, hemorrhage, and shock.
Blood Pressure: Hypertension and Hypotension
Normal blood pressure is 120/80 mm Hg. Elevated blood pressure is 120-129/under 80 mm Hg. Hypertension, warranting treatment at 130/80 mm Hg, is often asymptomatic and can lead to severe cardiovascular events, aneurysms, peripheral arterial disease, chronic renal disease, or cardiac...
953
Cardiopulmonary Resuscitation IV: Pharmacological Management01:25

Cardiopulmonary Resuscitation IV: Pharmacological Management

63
Pharmacologic intervention is crucial in treating cardiac arrest patients during ACLS or Advanced Cardiovascular Life Support. The ACLS algorithms guide the administration of specific drugs based on the patient's cardiac arrest rhythm, which includes pulseless ventricular tachycardia (VT), ventricular fibrillation (VF), asystole, and pulseless electrical activity (PEA).EpinephrineIndication: Epinephrine is the first-line drug for all cardiac arrest rhythms.Mechanism of Action: Epinephrine...
63
Flail Chest-II01:26

Flail Chest-II

222
Managing flail chest, a condition characterized by a segment of the chest wall moving independently from the rest of the thoracic cage, requires a comprehensive approach. It includes a thorough assessment of the patient's condition, a diagnostic evaluation to determine the extent of the injury, and the implementation of appropriate medical interventions tailored to the individual's needs.
Assessment:
1. Clinical Evaluation:
History:
222
Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

49
Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
49
Acute Kidney Injury III: Clinical Manifestations01:29

Acute Kidney Injury III: Clinical Manifestations

59
Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
59
Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care01:29

Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care

30
Diagnosing Pulmonary EmbolismDiagnosing pulmonary embolism (PE) involves clinical assessment and advanced imaging tests. The preferred diagnostic tool is the spiral (helical) CT scan or CT angiography (CTA), which uses intravenous contrast media to visualize the pulmonary vasculature and identify emboli.A ventilation-perfusion (V/Q) scan is an alternative for patients unable to receive contrast media. This scan includes both perfusion and ventilation scanning. Perfusion scanning involves...
30

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Venous Thrombus Embolism in Polytrauma: Special Attention to Patients with Traumatic Brain Injury.

Journal of clinical medicine·2023
Same author

Thoracic Spine Fractures with Blunt Aortic Injury: Incidence, Risk Factors, and Characteristics.

Journal of clinical medicine·2021
Same author

Endothelial Dysfunction and SARS-CoV-2 Infection: Association and Therapeutic Strategies.

Pathogens (Basel, Switzerland)·2021
Same author

Ameliorative effects of resveratrol against cadmium-induced nephrotoxicity via modulating nuclear xenobiotic receptor response and PINK1/Parkin-mediated Mitophagy.

Food & function·2020
Same author

`Cadmium induced cardiac inflammation in chicken (Gallus gallus) via modulating cytochrome P450 systems and Nrf2 mediated antioxidant defense.

Chemosphere·2020
Same author

Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury.

Science China. Life sciences·2020

Related Experiment Video

Updated: Aug 19, 2025

Pseudofracture: An Acute Peripheral Tissue Trauma Model
10:08

Pseudofracture: An Acute Peripheral Tissue Trauma Model

Published on: April 18, 2011

14.8K

Multifactorial Shock: A Neglected Situation in Polytrauma Patients.

Jialiu Luo1, Deng Chen1, Liangsheng Tang1

  • 1Department of Trauma Surgery, Tongji Trauma Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.

Journal of Clinical Medicine
|November 26, 2022
PubMed
Summary

Multifactorial shock, a combination of different shock types, occurs frequently in polytrauma patients. This condition significantly increases complication rates and mortality, requiring increased awareness among trauma specialists.

Keywords:
multifactorial shockpolytraumaretrospective studyshock

More Related Videos

Fixed Volume or Fixed Pressure: A Murine Model of Hemorrhagic Shock
16:31

Fixed Volume or Fixed Pressure: A Murine Model of Hemorrhagic Shock

Published on: June 6, 2011

25.0K
Author Spotlight: Developing Innovative Therapeutic Strategies for Hemorrhagic Shock Research
08:14

Author Spotlight: Developing Innovative Therapeutic Strategies for Hemorrhagic Shock Research

Published on: March 22, 2024

1.5K

Related Experiment Videos

Last Updated: Aug 19, 2025

Pseudofracture: An Acute Peripheral Tissue Trauma Model
10:08

Pseudofracture: An Acute Peripheral Tissue Trauma Model

Published on: April 18, 2011

14.8K
Fixed Volume or Fixed Pressure: A Murine Model of Hemorrhagic Shock
16:31

Fixed Volume or Fixed Pressure: A Murine Model of Hemorrhagic Shock

Published on: June 6, 2011

25.0K
Author Spotlight: Developing Innovative Therapeutic Strategies for Hemorrhagic Shock Research
08:14

Author Spotlight: Developing Innovative Therapeutic Strategies for Hemorrhagic Shock Research

Published on: March 22, 2024

1.5K

Area of Science:

  • Trauma and Emergency Medicine
  • Critical Care Medicine
  • Surgical Critical Care

Background:

  • Shock following trauma is often hypovolemic but can involve combinations of distributive, obstructive, and cardiogenic shock, termed multifactorial shock.
  • Multifactorial shock is understudied, with limited data on its incidence, characteristics, and outcomes in polytrauma.
  • Understanding multifactorial shock is crucial for improving patient management and outcomes in severe trauma.

Purpose of the Study:

  • To investigate the incidence, characteristics, and outcomes of multifactorial shock in polytrauma patients.
  • To compare the occurrence of different shock types in early and middle phases post-polytrauma.
  • To highlight the significance of multifactorial shock in trauma care.

Main Methods:

  • Retrospective, observational, multicenter study involving 1051 polytrauma patients.
  • Data collected from four Level I trauma centers between June 2020 and April 2022.
  • Analysis of shock types and patient outcomes based on Injury Severity Score (ISS) and time phases.

Main Results:

  • Hypovolemic shock dominated the early phase (≤48h), while distributive shock was most common in the middle phase (>48h to 14 days).
  • Multifactorial shock occurred in 9.7% of patients in the early phase and 15.2% in the middle phase.
  • Patients with multifactorial shock exhibited significantly higher complication rates and mortality compared to those with single-factor shock.

Conclusions:

  • Different shock types can coexist or follow each other sequentially in polytrauma.
  • Multifactorial shock presents a substantial incidence and elevated mortality risk in polytrauma.
  • Trauma specialists must remain vigilant for multifactorial shock to optimize patient care and outcomes.