Related Experiment Video

Updated: Aug 19, 2025

A Flow Cytometry-Based Cell Surface Protein Binding Assay for Assessing Selectivity and Specificity of an Anticancer Aptamer
10:46

A Flow Cytometry-Based Cell Surface Protein Binding Assay for Assessing Selectivity and Specificity of an Anticancer Aptamer

Published on: September 13, 2022

3.7K

Can Natural Products Targeting EMT Serve as the Future Anticancer Therapeutics?

Sirajudheen Anwar1,2, Jonaid Ahmad Malik3,4, Sakeel Ahmed5

  • 1Department of Pharmacology and Toxicology, College of Pharmacy, University of Hail, Hail 81422, Saudi Arabia.

Molecules (Basel, Switzerland)
|November 26, 2022
PubMed

Insights

Natural compounds from plants and marine sources show promise as alternative cancer treatments, potentially overcoming drug resistance by targeting epithelial-mesenchymal transition (EMT) mechanisms.

Area of Science:

  • Oncology and Natural Product Chemistry

Background:

  • Cancer remains a leading cause of death globally, with drug resistance posing a significant treatment challenge.
  • Dysregulation of cellular metabolism, cell cycle, apoptosis, and epigenetic alterations are hallmarks of cancer.
  • Natural products have garnered interest for their therapeutic potential in various diseases, including cancer.

Purpose of the Study:

  • To review and consolidate information on natural compounds from plant and marine sources.
  • To explore the anti-cancer potential of these natural compounds, focusing on their mechanisms related to epithelial-mesenchymal transition (EMT).

Main Methods:

  • Literature review of preclinical studies on natural compounds and their anti-cancer activities.
  • Analysis of research focusing on the role of natural products in modulating EMT pathways in cancer.

Main Results:

  • Natural substances derived from plants and marine environments exhibit significant anti-cancer activity in preclinical models.
  • These compounds may offer alternative therapeutic strategies to combat cancer, potentially by influencing EMT.

Conclusions:

  • Natural products represent a promising avenue for developing novel cancer therapeutics.
  • Further research into plant and marine-derived compounds targeting EMT mechanisms could lead to improved cancer treatments and overcome drug resistance.
Keywords:
anticancer therapycancercancer EMTchemotherapyepithelial-mesenchymal transitionnatural chemical entities

More Related Videos

Enhancement of Apoptotic and Autophagic Induction by a Novel Synthetic C-1 Analogue of 7-deoxypancratistatin in Human Breast Adenocarcinoma and Neuroblastoma Cells with Tamoxifen19:44

Enhancement of Apoptotic and Autophagic Induction by a Novel Synthetic C-1 Analogue of 7-deoxypancratistatin in Human Breast Adenocarcinoma and Neuroblastoma Cells with Tamoxifen

Published on: May 30, 2012

18.8K
Initial Evaluation of Antibody-conjugates Modified with Viral-derived Peptides for Increasing Cellular Accumulation and Improving Tumor Targeting11:58

Initial Evaluation of Antibody-conjugates Modified with Viral-derived Peptides for Increasing Cellular Accumulation and Improving Tumor Targeting

Published on: March 8, 2018

7.7K

Related Concept Videos

Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
6.6K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.8K
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.0K
Electron Transport Chain: Complex I and II01:46

Electron Transport Chain: Complex I and II

The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...
14.8K
Drugs that Stabilize Microtubules01:15

Drugs that Stabilize Microtubules

Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the spindle apparatus for segregating the chromosomes. This makes them ideal targets for regulating dividing cells in tumors and malignant cancer cells. Microtubule stabilizing drugs help stabilize the microtubule formation and promote its polymerization. Paclitaxel was the first microtubule stabilizing agent used as anticancer drug in chemotherapy...
2.1K
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
630