Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cascade Dielectrophoretic Separation for Selective Enrichment of Polyhydroxybutyrate (PHB)-Producing Cyanobacterium <i>Synechocystis</i> sp. PCC 6803.

Micromachines·2025
Same author

Interplay of the Mass Transport and Reaction Kinetics for Lateral Flow Immunoassay Integrated on Lab-on-Disc.

Sensors (Basel, Switzerland)·2025
Same author

Characterization of the Coating Layers Deposited onto Curved Surfaces Using a Novel Multi-Nozzle Extrusion Printer.

Micromachines·2025
Same author

Carbon-dot growth on nanoconvex carbon wires for outstanding optical properties.

Materials horizons·2025
Same author

Electrokinetic Manipulation of Biological Cells towards Biotechnology Applications.

Micromachines·2024
Same author

Doxorubicin Conjugated γ-Globulin Functionalised Gold Nanoparticles: A pH-Responsive Bioinspired Nanoconjugate Approach for Advanced Chemotherapeutics.

Pharmaceutics·2024

Related Experiment Video

Updated: Aug 19, 2025

Microfluidic Chips Controlled with Elastomeric Microvalve Arrays
18:11

Microfluidic Chips Controlled with Elastomeric Microvalve Arrays

Published on: October 1, 2007

21.2K

Microvalves for Applications in Centrifugal Microfluidics.

Snehan Peshin1, Marc Madou1,2, Lawrence Kulinsky1

  • 1Department of Mechanical and Aerospace Engineering, University of California, Irvine, CA 92697, USA.

Sensors (Basel, Switzerland)
|November 26, 2022
PubMed
Summary

Centrifugal microfluidic platforms (CDs) enable affordable point-of-care diagnostics. This review categorizes and evaluates valving systems crucial for controlling fluid flow in these essential CD diagnostic devices.

Keywords:
Lab-on-CDcentrifugal microfluidicsmicrofluidic valvingpoint-of-care diagnostics

More Related Videos

Author Spotlight: Integrating Computational and Experimental Approaches in Precision Oncology
07:03

Author Spotlight: Integrating Computational and Experimental Approaches in Precision Oncology

Published on: December 1, 2023

1.0K
Capillary-based Centrifugal Microfluidic Device for Size-controllable Formation of Monodisperse Microdroplets
08:20

Capillary-based Centrifugal Microfluidic Device for Size-controllable Formation of Monodisperse Microdroplets

Published on: February 22, 2016

10.4K

Related Experiment Videos

Last Updated: Aug 19, 2025

Microfluidic Chips Controlled with Elastomeric Microvalve Arrays
18:11

Microfluidic Chips Controlled with Elastomeric Microvalve Arrays

Published on: October 1, 2007

21.2K
Author Spotlight: Integrating Computational and Experimental Approaches in Precision Oncology
07:03

Author Spotlight: Integrating Computational and Experimental Approaches in Precision Oncology

Published on: December 1, 2023

1.0K
Capillary-based Centrifugal Microfluidic Device for Size-controllable Formation of Monodisperse Microdroplets
08:20

Capillary-based Centrifugal Microfluidic Device for Size-controllable Formation of Monodisperse Microdroplets

Published on: February 22, 2016

10.4K

Area of Science:

  • Microfluidics
  • Biotechnology
  • Diagnostic Devices

Background:

  • Centrifugal microfluidic platforms (CDs) are increasingly vital for inexpensive point-of-care (POC) diagnostics.
  • CDs integrate complex laboratory processes like PCR and plasma separation onto a single, portable disc.
  • Effective fluid control is essential for the reliability and scalability of CD-based diagnostics.

Purpose of the Study:

  • To review and categorize available fluidic valving systems for centrifugal microfluidic platforms.
  • To discuss the working principles, compatibility, and performance of various valving mechanisms.
  • To evaluate valving systems for their suitability in POC diagnostic applications on CDs.

Main Methods:

  • Literature review of fluidic valving systems.
  • Categorization of valves into active, passive, or hybrid based on actuation.
  • Analysis of valve performance parameters including actuation mechanism, physics, spin rate, and response time.

Main Results:

  • Valving systems are categorized by actuation: mechanical, thermal, hydrophobic/hydrophilic, solubility-based, and phase-change.
  • Key performance metrics such as actuation mechanism, governing physics, spin rate, and response time are discussed for each category.
  • Compatibility with CD platforms and applicability for functions like reagent storage and flow control are evaluated.

Conclusions:

  • Fluidic valves are critical for precise fluid control in centrifugal microfluidic devices.
  • Understanding valve principles and performance is key to designing robust and scalable CD diagnostic platforms.
  • The choice of valving system impacts the integration of multiple processes and specialized functions on a single CD.