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Association between sensitivity to thyroid hormones and dyslipidemia in patients with coronary heart disease

Yijia Liu1, Mei Ma1, Lin Li1

  • 1Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China.

Endocrine
|November 26, 2022
PubMed

Insights

Thyroid hormone sensitivity is linked to dyslipidemia in coronary heart disease patients. Increased sensitivity markers correlate with higher dyslipidemia risk, while lower sensitivity markers show the opposite effect.

Area of Science:

  • Endocrinology
  • Cardiovascular Medicine
  • Metabolic Disorders

Background:

  • Thyroid hormones play a crucial role in regulating lipid metabolism.
  • Limited research exists on the connection between thyroid hormone sensitivity and dyslipidemia.
  • This study investigates this association in patients with coronary heart disease (CHD).

Purpose of the Study:

  • To examine the relationship between central and peripheral thyroid hormone sensitivity and the prevalence of dyslipidemia.
  • To identify specific markers of thyroid hormone sensitivity associated with dyslipidemia risk in CHD patients.

Main Methods:

  • A large-scale, multicenter retrospective study involving 31,678 CHD patients.
  • Central thyroid hormone sensitivity assessed using TFQI, PTFQI, TSHI, and TT4RI.
  • Peripheral thyroid hormone sensitivity evaluated by the FT3/FT4 ratio; logistic regression used for analysis.

Main Results:

  • A high prevalence of dyslipidemia (68.34%) was observed in the study cohort.
  • Positive correlations found between TFQI, PTFQI, TSHI, TT4RI and dyslipidemia risk.
  • Negative correlation observed between FT3/FT4 ratio and dyslipidemia risk, significant across subgroups.

Conclusions:

  • A significant association exists between thyroid hormone sensitivity and dyslipidemia in CHD patients.
  • This association is independent of patient sex, glucose levels, and blood pressure status.
  • Findings highlight the importance of assessing thyroid hormone sensitivity in managing dyslipidemia in cardiovascular disease.
Abstract

Keywords:
Coronary heart diseaseDyslipidemiaElevated blood glucoseHypertensionResistance to thyroid hormonesThyroid hormone sensitivity

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