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Updated: Aug 19, 2025
A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy
Published on: November 13, 2016
Association between multiple sclerosis and epilepsy: A systematic review and meta-analysis
Stephanie Kuntz1, Annie Siyu Wu2, Emilie Matheson3
1Division of Neurology, Department of Medicine, University of Toronto, Toronto, ON, Canada.
People with multiple sclerosis (MS) have a significantly higher risk of developing epilepsy. This systematic review confirms MS as an independent risk factor for both new and existing epilepsy cases.
Area of Science:
- Neurology
- Epidemiology
- Neuroimmunology
Background:
- Epilepsy risk in adults with multiple sclerosis (MS) is not well-defined.
- Understanding this association is crucial for patient care and management.
Approach:
- A systematic review and meta-analysis was conducted.
- Searched MEDLINE and EMBASE for observational studies up to July 2022.
- Included 17 studies with 192,850 adults with and without MS.
Key Points:
- Adults with MS had a 2.04 times higher prevalence of epilepsy.
- Adults with MS had a 3.34 times higher incidence of epilepsy.
- Moderate study quality noted; MS type and seizure types were often unspecified.
Conclusions:
- Multiple sclerosis is an independent risk factor for epilepsy.
- Further longitudinal studies are needed to identify specific patient and disease characteristics.
- Grey matter involvement may influence epilepsy risk in MS.
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