Association Between Behçet's Disease and Depression
Bar Pitaro Alter1, Shmuel Tiosano1, Yuval Kuntzman1
1Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel Hashomer, Israel, Internal Medicine B, Sheba Medical Center, Tel Hashomer, Israel, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
The Israel Medical Association Journal : IMAJ
|November 27, 2022
Summary
People with Behçet's disease (BD) have a higher likelihood of experiencing depression. This association is particularly strong in younger adults and those with specific socioeconomic factors, highlighting the need for integrated care.
Area of Science:
- Rheumatology
- Psychiatry
- Epidemiology
Background:
- Behçet's disease (BD) is a chronic, multisystemic vasculitic disorder of unknown cause.
- BD commonly presents with oral aphthae, genital ulcers, and uveitis.
- Psychiatric manifestations, such as depression, can occur in BD patients.
Purpose of the Study:
- To investigate the association between Behçet's disease and depression.
- To adjust for known risk factors for depression in this analysis.
Main Methods:
- A cross-sectional study was conducted using the Clalit Health Services database in Israel.
- 873 BD patients were matched with 4369 controls based on age and sex.
Main Results:
- Depression rates were significantly higher in BD patients (9.39%) compared to controls (5.49%), with an odds ratio (OR) of 1.79.
- Multivariable analysis confirmed a significant association between BD and depression (OR 1.83).
- The BD-depression association was most pronounced in younger adults (18-39), individuals of low/high socioeconomic status, and non-smokers.
Conclusions:
- A significant association exists between Behçet's disease and depression.
- This relationship necessitates a holistic and multidisciplinary approach to patient care.
- Clinical management of BD should incorporate screening and treatment for depression.
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